4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]benzamide
4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]benzamide
- CAS:
- 188591-46-0
- MF:
- C15H12ClF3N2O3S
- MW:
- 392.78
Suppliers by country/region
Company Type
Properties
- Boiling point:
- 585.1±50.0 °C(Predicted)
- Density
- 1.448±0.06 g/cm3 (20 ºC 760 Torr)
- storage temp.
- 2-8°C
- solubility
- DMSO: ≥10mg/mL
- pka
- 12.92±0.46(Predicted)
- form
- White solid
- color
- white to off-white
- Stability:
- Stable for 1 year for up to year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H319
- Precautionary statements
- P264-P280-P305+P351+P338-P337+P313P
- Hazard Codes
- Xi
- Risk Statements
- 36
- Safety Statements
- 26
- WGK Germany
- 3
Use
PPARβ/δ is thought to play a role in lipid homeostasis and glucose disposal by regulating genes involved in fatty acid oxidation, reverse cholesterol transport, and carbon substrate utilization in skeletal muscle. It has also been implicated in the progression of certain cancers. GSK3787 is an irreversible antagonist of PPARβ/δ (pIC50 = 6.6) with no measurable affinity for PPARα or PPARγ (pIC50 5). At 1μM, it inhibits the expression of PPARβ/δ-regulated target genes, pyruvate dehydrogenase kinase 4 and carnitine palmitoyl transferase 1a, which are important for energy homeostasis in human skeletal muscle cells. GSK3787 (at 1 μM) also antagonizes agonist-induced expression of angiopoietin-like protein 4 in mouse fibroblasts, mouse keratinocytes, and human MCF-7, Huh7, and HepG2 cancer cell lines.[Cayman Chemical]
1 India supplier list of "4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]benzamide"
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- Product Name:PPARβ/δAntagonist,GSK3787-CAS188591-46-0-Calbiochem
- Products Intro:Brand:sigma aldrich | Product Number:516567 | Purity:ThePPARβ/δAntagonistII,PT-S58,alsoreferencedunderCAS188591-46-0,controlsthebiolo
- Company Type: Trader
- Country/Region: Bangalore,INDIA
- Product Name:4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]benzamide
- Products Intro:Purity: 99% | Package: 1.8KG;9.8USD
- Company Type: Trader
- Country/Region: CHINA
$9.80/ 1.8KG
- Product Name:GSK3787
- Products Intro:Purity: 98.05% | Package: 1 mL * 10mM (in DMSO);10 mg;100 mg;25 mg;5 mg;50 mg | CustNote: REAGENT;FOR LABORATORY USE ONLY
- Company Type: Trader
- Country/Region: UNITED STATES
- Main Products: Compound Libraries,Noval Small Molecucles,Nature Compounds,Inhibitory Antibodies,Life science Kits