Aminopterin
Aminopterin
- CAS:
- 54-62-6
- MF:
- C19H20N8O5
- MW:
- 440.41
Suppliers by country/region
Company Type
Properties
- Melting point:
- 225 °C
- alpha
- 18 º (c=1% in 0.1N NaOH)
- Boiling point:
- 551.67°C (rough estimate)
- Density
- 1.4378 (rough estimate)
- refractive index
- 1.6910 (estimate)
- Flash point:
- 87℃
- storage temp.
- -20°C
- solubility
- 2 M NaOH: 50 mg/mL
- form
- powder
- pka
- pKa 5.5 (Uncertain)
- color
- yellow
- Merck
- 14,472
- BRN
- 69045
Safety Information
- Symbol(GHS)
GHS06,GHS08
- Signal word
- Danger
- Hazard statements
- H300-H360
- Precautionary statements
- P201-P280-P301+P330+P331+P310-P308+P313
- Hazard Codes
- T+
- Risk Statements
- 61-28-63-26/27/28
- Safety Statements
- 53-28-36/37-45-36/37/39-22
- RIDADR
- UN 2811 6.1/PG 1
- WGK Germany
- 3
- RTECS
- MA1050000
- F
- 8-10-23
- HazardClass
- 6.1(a)
- PackingGroup
- I
- HS Code
- 29339900
- Toxicity
- LDLo orl-rat: 2500 mg/kg JPETAB 95,303,49
Use
Aminopterin is used as antineoplastic, antirheumatic, folic acid antagonist. Its actively transported into cells by thefolate transporter. In the cell, its converted to a high molecular weight polyglutamate metabolite by folylpolyglutamate synthase, that, in turn, binds to dihydrofolate reductase and inhibits its activity.
2 India supplier list of "Aminopterin"
- Product Name:Methotrexate EP Impurity-B
- Products Intro:Purity: 98% | Package: 50 MG; 100 MG; 250 MG ; 1 GM
- Company Type: Manufacturer
- Country/Region: INDIA
- Product Name:Aminopterin
- Products Intro:Brand:sigma aldrich | Product Number:A1784 | Purity:powder
- Company Type: Trader
- Country/Region: INDIA
- Product Name:3-AminoPterin(4-AminoFolicAcid)
- Products Intro:Brand:cdhfinechemical | Product Number:008555
- Company Type: Trader
- Country/Region: INDIA
- Product Name:Aminopterin
- Products Intro:Brand:pharmaffiliates | Product Number:PA1328020
- Company Type: Trader
- Country/Region: INDIA
- Product Name:Aminopterin
- Company Type: Reagent
- Country/Region: INDIA
- Product Name:MethotrexateEPImpurityB
- Products Intro:Brand:clearsynth | Product Number:CS-M-42743
- Company Type: Trader
- Country/Region: INDIA
- Product Name:Aminopterin
- Products Intro:Brand:tcichemicals | Product Number:A0410
- Company Type: Reagent
- Country/Region: INDIA
- Product Name:MethotrexateEPImpurityB
- Products Intro:Brand:synzeal | Product Number:123954216
- Company Type: Trader
- Country/Region: INDIA
- Product Name:Aminopterin
- Products Intro:Purity: 98% | Package: 1g,10g,25g,100g,500g,1kg
- Company Type: Trader
- Country/Region: CHINA
- Product Name:Methotrexate Impurity B
- Products Intro:Purity: > 95% | Package: 500 mg | CustNote: BOC Sciences also provides custom synthesis services for Methotrexate Impurity B.
- Company Type: Trader
- Country/Region: UNITED STATES