Ampicillin manufacturers and suppliers in india

Ampicillin

Properties

Melting point:: 198-200 °C (dec.)(lit.)

alpha: D23 +287.9° (c = 1 in water)

Boiling point:: 201.8°C (rough estimate)

Density: 1.2794 (rough estimate)

refractive index: 1.6320 (estimate)

storage temp.: 2-8°C

solubility: NH₄OH 1 M: 50 mg/mL, clear, colorless

form: solid

color: White to Pale Yellow

pka: 2.5 (COOH)(at 25℃)

Water Solubility: 13.9g/L(25 ºC)

JECFA Number: 85

Merck: 13,591

BRN: 1090925

Stability:: Stable, but may be moisture sensitive. Incopmpatible with strong oxidizing agents.

InChIKey: AVKUERGKIZMTKX-NJBDSQKTSA-N

Safety Information

Symbol(GHS): GHS08

Signal word: Danger

Hazard statements: H317-H334

Precautionary statements: P261-P272-P280-P284-P302+P352-P333+P313

Hazard Codes: Xn,T

Risk Statements: 36/37/38-42/43-61

Safety Statements: 22-26-36/37-45-53

WGK Germany: 2

RTECS: XH8425000

F: 10-23

HS Code: 29212900

Toxicity: LD50 oral in mouse: > 5gm/kg

Use

Ampicillin is a β-lactam antibiotic within the penicillin family. As a member of this family, Ampicillin is susceptible to β-lactamase, which hydrolyzes the β-lactam ring. This broad spectrum antibiotic is effective against gram-positive, gram-negative bacteria and anaerobic bacteria. Ampicillin is widely used in cell culture as a selective agent. As an antibiotic, Ampicillin binds to penicillin binding proteins (PBPs) on a susceptible organism and Inhibits bacterial cell-wall synthesis by inactivating transpeptidases on the inner surface of the bacterial cell membrane. After binding to the PBPs, Ampicilin acts as a structural analogue of acyl-D-alanyl-D-alanine, acylates the transpeptidase enzyme and thereby prevents the cross-linking of the peptidoglycan of the cell wall necessary for the growth of the bacterium.