Candesartan cilexetil
Candesartan cilexetil
- CAS:
- 145040-37-5
- MF:
- C33H34N6O6
- MW:
- 610.66
Suppliers by country/region
Company Type
Properties
- Melting point:
- 168-170?C
- Boiling point:
- 843.3±75.0 °C(Predicted)
- Density
- 1.37±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: ≥15mg/mL
- pka
- pKa 3.55 (H2O t=25.0 I=0.025) (Uncertain);5.91(H2O t=25.0 I=0.025) (Uncertain)
- form
- powder
- color
- white to beige
- λmax
- 304nm(EtOH)(lit.)
- Merck
- 14,1739
- BCS Class
- 2
- InChIKey
- GHOSNRCGJFBJIB-UHFFFAOYSA-N
- SMILES
- C1(OCC)N(CC2=CC=C(C3=CC=CC=C3C3=NNN=N3)C=C2)C2=C(C(OC(OC(OC3CCCCC3)=O)C)=O)C=CC=C2N=1
Safety Information
- Symbol(GHS)
GHS08,GHS09
- Signal word
- Warning
- Hazard statements
- H361-H400
- Precautionary statements
- P280
- Hazard Codes
- Xn,N,T
- Risk Statements
- 20/21/22-36/37/38-50-48/20-61
- Safety Statements
- 26-36-61-45-53
- WGK Germany
- 3
- RTECS
- DD6672500
- HS Code
- 29339953
- Toxicity
- dog,LD50,oral,> 2gm/kg (2000mg/kg),Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 42, Pg. 406, 2000.
Use
Candesartan cilexetil is a kind of prodrug being hydrolyzed to candesartan during absorption from the gastrointestinal tract. It appears as a white or off-white powder with a molecular weight of 610.67. It is soluble in methanol but insoluble in water. It is a kind of selective AT1 subtype angiotensin II receptor antagonist, mainly used for the treatment of hypertension and heart failure. Candesartan cilexetil takes effects through selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues, such as vascular smooth muscle and the adrenal gland, further blocking the vasoconstrictor and aldosterone-secreting effects of angiotensin II. Therefore, its mode of action is not through interfering with the pathways for angiotensin II synthesis. Candesartan cilexetil may lead to various kinds of adverse reactions including headache, back pain, dizziness, upper respiratory tract infection, pharyngitis, rhinitis, bronchitis, coughing, sinusitis, nausea, abdominal pain, diarrhea, vomiting, arthralgia and albuminuria. It should be warned that candesartan cilexetil might have remarkable fetal toxicity. Therefore, upon pregnancy, candesartan cilexetil should be discontinued. It could also cause hypotension for heart-failure patients.
87 India supplier list of "Candesartan cilexetil "
- Product Name:Candesartan Cilexetil
- Products Intro:Purity: 98% | Package: 50 MG; 100 MG; 250 MG ; 10 GM
- Company Type: Manufacturer
- Country/Region: Hyderabad,INDIA
- Product Name:Candesartan cilexetil
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Maharashtra,INDIA
- Product Name:Candesartan cilexetil
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and MT
- Company Type: Manufacturer
- Country/Region: Maharashtra,INDIA
- Product Name:Candesartan cilexetil
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg
- Company Type: Reagent
- Country/Region: New Delhi,INDIA
- Product Name:Candesartan cilexetil
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Gujarat,INDIA
- Product Name:Candesartan cilexetil
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Maharashtra,INDIA
- Product Name:Candesartan cilexetil
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg
- Company Type: Manufacturer
- Country/Region: Gujarat,INDIA
- Product Name:Candesartan cilexetil
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg
- Company Type: Reagent
- Country/Region: Punjab,INDIA
- Product Name:Candesartan Cilexetil 1-[[(Cyclohexyloxy)carbonyl]oxy]ethyl 2-ethoxy-1-[[2'-(1H- tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7- carboxylate
- Products Intro:Purity: 96% | Package: 25 mg, 50 mg , 100mg or 500 mg
- Company Type: Manufacturer
- Country/Region: Maharashtra,INDIA
- Product Name:CANDESARTAN CILEXETIL
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Hyderabad,INDIA