Cantharidin manufacturers and suppliers in india

Cantharidin

Properties

Melting point:: 215-217 °C (lit.)

Boiling point:: 253.08°C (rough estimate)

Density: 1.0357 (rough estimate)

refractive index: 1.4699 (estimate)

storage temp.: 2-8°C

solubility: Soluble in DMSO (25 mg/ml warm), acetone (8 mg/ml), ethanol (8 mg/ml warm), chloroform (1:65), ether (1:560), and ethyl acetate (1:150).

form: solution

color: white

Water Solubility: 30mg/L(20 ºC)

Merck: 14,1752

Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 weeks.

InChIKey: DHZBEENLJMYSHQ-XCVPVQRUSA-N

LogP: -0.409 (est)

Safety Information

Symbol(GHS): GHS06

Signal word: Danger

Hazard statements: H300-H315-H319-H335

Precautionary statements: P261-P264-P270-P301+P310-P302+P352-P305+P351+P338

Hazard Codes: T+,T

Risk Statements: 28-36/37/38-38-37-36-23/24/25

Safety Statements: 53-45-36/37/39

RIDADR: UN 2811 6.1/PG 1

WGK Germany: 3

RTECS: RN8575000

TSCA: Yes

HazardClass: 6.1(a)

PackingGroup: I

HS Code: 29329990

Use

Cantharidin is a natural toxicant of blister beetles. Cantharidin has been used as a medicinal agent for over 2000 years and is listed as a drug under the name of Mylabris in the medical monograph Materia Medica published in 77 AD. Some of the most ancient Chinese prescriptions (306168 BC) refer to the use of Mylabris for the treatment of furuncles and piles. Cantharidin can be used for topically (0.7%) treatment of warts, in which the skin under the wart blisters, thereby, lifting the wart off the skin. It is used to treat molluscum contagiosum. Cantharidin is a strong inhibitor of protein phosphatases types 1 (PP1) and 2A (PP2A), which are potentially novel targets for anticancer therapies. Thus, cantharidin is exploited as anticancer drugs. Cantharidin is shown to be cytotoxic to cancer cells and stimulatory on the bone marrow. The renal toxicity of this drug has prevented its use in mainstream oncology.