Cephalothin
Cephalothin
- CAS:
- 153-61-7
- MF:
- C16H16N2O6S2
- MW:
- 396.44
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Properties
- Melting point:
- 160-161 ºC
- alpha
- D20 +50° (c = 1.03 in acetonitrile)
- Boiling point:
- 757.2±60.0 °C(Predicted)
- Density
- 1.4162 (rough estimate)
- refractive index
- 1.6510 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- DMSO (Sparingly), Dioxane (Slightly), Methanol (Slightly)
- pka
- pKa 2.5 (Uncertain)
- form
- Solid
- color
- White to Off-White
- Water Solubility
- 158 MG/L
- λmax
- 263nm(H2O)(lit.)
- Merck
- 14,1982
Safety Information
- Symbol(GHS)
GHS08
- Signal word
- Warning
- Hazard statements
- H317-H334
- Precautionary statements
- P261-P272-P280g-P285-P302+P352-P304+P341-P333+P313-P342+P311-P363-P403-P501c
- RTECS
- XI0388000
- Toxicity
- LD50 intracrebral in mouse: 81mg/kg
Use
Cephalothin is a semisynthetic, beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity. Cephalothin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.
13 India supplier list of "Cephalothin"
- Product Name:Cephalothin
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg
- Company Type: Manufacturer
- Country/Region: Punjab,INDIA
- Product Name:Cephalothin >98% (HPLC)
- Products Intro:Brand：Glrinnovations | OriginalID：GLR19.071530
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:Cephalothin
- Products Intro:Purity: >98.0% | Package: 5g, 25g
- Company Type: Reagent
- Country/Region: New Delhi,INDIA
- Product Name:(6R,7R)-3-(Acetoxymethyl)-8-oxo-7-(2-(thiophen-2-yl)acetamido)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:Cephalothin
- Company Type: Reagent
- Country/Region: Maharashtra,INDIA
- Product Name:Cephalothin
- Company Type: Reagent
- Country/Region: Gujarat,INDIA
- Product Name:Cephalothin
- Company Type: Reagent
- Country/Region: Gujarat,INDIA
- Product Name:Cephalothin
- Company Type: Reagent
- Country/Region: Haryana,INDIA
- Product Name:Cephalothin
- Products Intro:Brand:clearsynth | Product Number:CS-T-10897
- Company Type: Trader
- Country/Region: Hyderabad,INDIA
- Product Name:Cephalothin
- Company Type: Reagent
- Country/Region: Mumbai,INDIA