Ethionamide
Ethionamide
- CAS:
- 536-33-4
- MF:
- C8H10N2S
- MW:
- 166.24
Suppliers by country/region
Company Type
Properties
- Melting point:
- 164 °C
- Boiling point:
- 167 °C / 1mmHg
- Density
- 1.1332 (rough estimate)
- refractive index
- 1.5500 (estimate)
- Flash point:
- >110°(230°F)
- storage temp.
- 2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- pKa 4.37(H2O t=25.0 I=0.025) (Uncertain)
- color
- Yellow
- Water Solubility
- Soluble in DMSO. Sparingly soluble in water
- Merck
- 14,3737
- BCS Class
- 3/1
- InChIKey
- AEOCXXJPGCBFJA-UHFFFAOYSA-N
Safety Information
- Symbol(GHS)
GHS07,GHS08
- Signal word
- Warning
- Hazard statements
- H302-H361
- Precautionary statements
- P280-P301+P312+P330
- Hazard Codes
- Xn
- Risk Statements
- 22-63
- Safety Statements
- 36/37
- WGK Germany
- 3
- RTECS
- NS0350000
- HS Code
- 29333990
- Toxicity
- LD50 oral in rat: 1320mg/kg
Use
2-Ethylthioisonicotinamide (Trecator SC) occurs as a yellowcrystalline material that is sparingly soluble in water. Thisnicotinamide has weak bacteriostatic activity in vitro but, becauseof its lipid solubility, is effective in vivo. In contrast tothe isoniazid series, 2-substitution enhances activity in thethioisonicotinamide series.Ethionamide is rapidly and completely absorbed followingoral administration. It is widely distributed throughoutthe body and extensively metabolized to predominantly inactiveforms that are excreted in the urine. Less than 1% ofthe parent drug appears in the urine.Ethionamide is considered a secondary drug for the treatmentof tuberculosis. It is used in the treatment of isoniazidresistanttuberculosis or when the patient is intolerant toisoniazid and other drugs. Because of its low potency, thehighest tolerated dose of ethionamide is usually recommended.Gastrointestinal intolerance is the most commonside effect associated with its use. Visual disturbances andhepatotoxicity have also been reported.
21 India supplier list of "Ethionamide"
![](/images/pro-3.jpg)
- Product Name:Ethionamide
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Maharashtra,INDIA
![](/images/pro-3.jpg)
- Product Name:Ethionamide
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Maharashtra,INDIA
![](/images/pro-3.jpg)
- Product Name:Ethionamide
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT | CustNote: Tech pack under preparation
- Company Type: Manufacturer
- Country/Region: Maharashtra,INDIA
![](/images/pro-3.jpg)
- Product Name:Ethionamide
- Products Intro:Brand:sigma aldrich | Product Number:E6005
- Company Type: Trader
- Country/Region: Bangalore,INDIA
![](/images/pro-3.jpg)
- Product Name:Ethionamide
- Company Type: Reagent
- Country/Region: Mumbai,INDIA
![](/images/pro-3.jpg)
- Product Name:Ethionamide
- Company Type: Reagent
- Country/Region: Maharashtra,INDIA