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Etomidate
Etomidate
- CAS:
- 33125-97-2
- MF:
- C14H16N2O2
- MW:
- 244.29
Properties
- Melting point:
- 72-74°C
- alpha
- D20 +66° (c = 1 in ethanol)
- Boiling point:
- 160-162 °C(Press: 1 Torr)
- Density
- 1.11±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: >10 mg/mL
- form
- powder
- pka
- pKa 4.24(H2O t=25.0) (Uncertain)
- color
- white
- Merck
- 14,3881
Safety Information
- Symbol(GHS)
GHS07,GHS09
- Signal word
- Warning
- Hazard statements
- H302-H400
- Precautionary statements
- P301+P312+P330
- Hazard Codes
- Xn
- Risk Statements
- 22
- Safety Statements
- 36
- RIDADR
- UN 3077 9 / PGIII
- WGK Germany
- 3
- RTECS
- NI4021500
- HazardClass
- 9
- PackingGroup
- III
- HS Code
- 29332900
- Toxicity
- LD50 in mice, rats (mg/kg): 29.5, 14.8-24.3 i.v. (Janssen)
Use
Etomidate is an ultra-short effect non-barbiturate intravenous anesthetic agent allowed to be used in China , it belongs to imidazole derivatives. Hypnotic effect of Etomidate is strong , and its efficacy is about 12 times higher than thiopental, it has no analgesic effect. It has a rapid onset of anesthesia, after 20 seconds of intravenous injection, it produces anesthesia, anesthesia is maintained for about 5 minutes, it is quick to wake up , increasing the dose will increase the duration of action accordingly.
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