Flutamide manufacturers and suppliers in india

Flutamide

Properties

Melting point:: 112 °C

Boiling point:: 400.3±45.0 °C(Predicted)

Density: 1.3649 (estimate)

storage temp.: 2-8°C

solubility: Practically insoluble in water, freely soluble in acetone and in ethanol (96 per cent).

pka: 13.12±0.70(Predicted)

form: Solid

color: Pale Yellow to Light Yellow

Merck: 14,4208

InChI: InChI=1S/C11H11F3N2O3/c1-6(2)10(17)15-7-3-4-9(16(18)19)8(5-7)11(12,13)14/h3-6H,1-2H3,(H,15,17)

InChIKey: MKXKFYHWDHIYRV-UHFFFAOYSA-N

SMILES: C(NC1=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1)(=O)C(C)C

Safety Information

Symbol(GHS): GHS07,GHS08,GHS09

Signal word: Warning

Hazard statements: H302-H351-H361-H373-H411

Precautionary statements: P202-P260-P264-P273-P301+P312-P308+P313

Hazard Codes: Xn,Xi

Risk Statements: 20/21/22-63-36/37/38

Safety Statements: 22-36-36/37/39-27-26

WGK Germany: 3

RTECS: UG5700000

HS Code: 29242990

Use

Flutamide is a kind of synthetic, non-steroidal antiandrogen which is mainly used for the treatment of prostate cancer. It is a kind of toluidine derivative and a nonsteroidal antiandrogen with a similar structure of bicalutamide and nilutamide. The mechanism of its anti-cancer property is through acting as a selective antagonist of the androgen receptor (AR), preventing androgens such as testosterone and its active metabolite dihydrotestosterone from binding to ARs in the prostate gland.