GNE-3511
GNE-3511
- CAS:
- 1496581-76-0
- MF:
- C23H26F2N6O
- MW:
- 440.49
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Company Type
Properties
- Boiling point:
- 579.0±50.0 °C(Predicted)
- Density
- 1.37±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:25.63(Max Conc. mg/mL);58.18(Max Conc. mM)
Methanol:1.0(Max Conc. mg/mL);2.27(Max Conc. mM)
- form
- A crystalline solid
- pka
- 7.23±0.40(Predicted)
- color
- Light yellow to yellow
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H302-H315-H319-H335
- Precautionary statements
- P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501
- HS Code
- 2934999090
Use
GNE-3511 is a selective and highly potent inhibitor of dual leucine zipper kinase (DLK). It also inhibits phosphorylated JNKand is highly selective for DLK over other MAP kinases. In an MPTP mouse model of Parkinsons disease, a high dose of GNE-3511 completely suppresses phosphorylated c-Jun (p-c-Jun) expression, while a low dose moderately reduces its expression. Study has also shown that GNE03511 displayed concentration-dependent protection of neurons from degeneration in vitro and demonstrated dose-dependent activity in two different animal models of disease. These results suggest that GNE-3511 may have therapeutic potential in multiple indications.
0 India supplier list of "GNE-3511"
- Product Name:GNE-3511
- Products Intro:Purity: 98% | Package: 10MG;50MG;100MG,1G,5G,10G.100G
- Company Type: Reagent
- Country/Region: CHINA
- Product Name:GNE-3511
- Products Intro:Purity: 98% | Package: 50mg | CustNote: BOC Sciences also provides custom synthesis services for GNE-3511.
- Company Type: Trader
- Country/Region: UNITED STATES
- Product Name:GNE-3511
- Products Intro:Purity: 99% | Package: 5KG;1KG | CustNote: GNE-3511
- Company Type: Trader
- Country/Region: CHINA
- Main Products: sarms
- Product Name:GNE-3511
- Products Intro:Purity: NLT 98% | Package: 1G;100G;1KG;50KG | CustNote: MC714376
- Company Type: Manufacturer
- Country/Region: CHINA
- Main Products: 2432-11-3,1052686-50-6,2198-53-0,3769-42-4,83647-42-1
- Product Name:GNE-3511
- Products Intro:Purity: 98 | Package: 500mg；1g；5g；10g；25g | CustNote: Provide customized services
- Company Type: Trader
- Country/Region: CHINA
- Product Name:GNE-3511
- Products Intro:Purity: 0 | Package: 1g; 5g; 25g; 1kg; 5kg; 25kg | CustNote: 0
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Pharmaceutical intermediate
- Product Name:GNE-3511
- Products Intro:Purity: 99% | Package: $90.9/10mg;$150.9/25mg;$250.9/50mg;$400.9/100mg;Bulk package | CustNote: 99%
- Company Type: Trader
- Country/Region: UNITED STATES
- Main Products: Chemicals and BioChemicals,Materials Science,ligands acting on targets,Proteins,Antibodies
- Product Name:GNE-3511
- Products Intro:Purity: 0.98 | Package: 10G:100G
- Company Type: Trader
- Country/Region: CHINA
- Main Products: MRTX1133,(cas:2055858-27-8)1,1′-Sulfinylbis[3,5-difluorobenzene,(cas:17220-38-1) 3,4-Diaminofurazane,Mirogabalin besylate,AK2292
- Product Name:GNE-3511
- Products Intro:Purity: 0.97 | Package: mgs,gs,kgs | CustNote: A905133
- Company Type: Reagent
- Country/Region: CHINA
-
1 mg$34.00
- Product Name:GNE-3511
- Products Intro:Brand：Caymanchem | Product Number：19174 | Purity：≥98%
- Company Type: Trader
- Country/Region: UNITED STATES