GSK 189254A
GSK 189254A
- CAS:
- 720690-73-3
- MF:
- C21H25N3O2
- MW:
- 351.44
Suppliers by country/region
Company Type
Properties
- Boiling point:
- 545.0±50.0 °C(Predicted)
- Density
- 1.195±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:25.0(Max Conc. mg/mL);71.13(Max Conc. mM)
- form
- A solid
- pka
- 14.26±0.46(Predicted)
- color
- White to off-white
Safety Information
Use
GSK189254A is a histamine H3 receptor antagonist for the treatment of narcolepsy.It may also be useful for the treatment of dementia and neuropathic pain. Its pharmacological effect may be related to its effect on increasing the release neurotransmitter in the brain. Microdialysis studies demonstrated that GSK189254 increased the release of acetylcholine, noradrenaline, and dopamine in the anterior cingulate cortex and acetylcholine in the dorsal hippocampus. GSK189254 significantly improved performance of rats in diverse cognition paradigms, including passive avoidance, water maze, object recognition, and attentional set shift. These data suggest that GSK189254 may have therapeutic potential for the symptomatic treatment of dementia in Alzheimers disease and other cognitive disorders.
0 India supplier list of "GSK 189254A"
- Product Name:GSK 189254A
- Products Intro:Purity: 98% | Package: 10MG;50MG;100MG,1G,5G,10G
- Company Type: Reagent
- Country/Region: CHINA
- Product Name:GSK 189254A
- Products Intro:Purity: 98% | Package: 300mg | CustNote: BOC Sciences also provides custom synthesis services for GSK 189254A.
- Company Type: Trader
- Country/Region: UNITED STATES
- Product Name:GSK 189254A
- Products Intro:Package: 1g; 5g; 25g; 1kg; 5kg; 25kg
- Company Type: Trader
- Country/Region: CHINA
- Main Products: pharmaceuticals,intermediates,fine chemicals,screening compounds,building blocks
- Product Name:6-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-N-methylpyridine-3-carboxamide
- Products Intro:Purity: 0.98 | Package: 100KG;25KG;10KG;1KG
- Company Type: Trader
- Country/Region: CHINA
-
100 mg$600.00250 mg$1100.00
- Product Name:GSK189254A
- Products Intro:Brand：dcchemicals | Product Number：DC10102 | Purity：>98%
- Company Type: Trader
- Country/Region: UNITED STATES
- Product Name:GSK189254A
- Products Intro:Brand：chiralstar | Product Number：scs-2905
- Company Type: Trader
- Country/Region: UNITED STATES
-
1mg$60.005mg$100.0010mg$150.0050mg$450.00100mg$650.00
- Product Name:GSK189254A
- Products Intro:Brand：ChemScene | Product Number：CS-6206 | Purity：98.45%
- Company Type: Trader
- Country/Region: UNITED STATES
-
1 g$1500.00
- Product Name:6-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yloxy)-N-methylpyridine-3-carboxamide
- Products Intro:Brand：abosyn | Product Number：30-2175 | Purity：98-99%
- Company Type: Trader
- Country/Region: UNITED STATES
- Product Name:6-((3-cyclobutyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)oxy)-N-methylnicotinamide
- Products Intro:Brand：ChemShuttle
- Company Type: Trader
- Country/Region: UNITED STATES
-
1mg$136.00
- Products Intro:Brand:1pchem | Product Number:1P00FG9H | Purity:98%
- Company Type: Trader
- Country/Region: UNITED STATES