LYCORINE manufacturers and suppliers in india

LYCORINE

Properties

Melting point:: 253-255℃ (dec.)

alpha: D16 -129° (c = 0.16 in 98% alc)

Boiling point:: 429.61°C (rough estimate)

Density: 1.53

refractive index: 1.5500 (estimate)

storage temp.: 2-8°C

solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

pka: 13.55±0.40(Predicted)

form: powder

color: White to off-white

optical activity: -12916 (c 0.16, 98% ethanol)

Safety Information

Symbol(GHS): GHS06

Signal word: Danger

Hazard statements: H301

Precautionary statements: P264-P270-P301+P310-P321-P330-P405-P501

Hazard Codes: T

Risk Statements: 25

Safety Statements: 45

RIDADR: UN 2811 6.1/PG 3

WGK Germany: 3

Use

Lycorine is an analgesic, more so than aspirin, and a hypotensive, as are caranine and galanthine . The analgesic activity exhibited by the Amaryllidaceae alkaloids is attributed to their resemblance to the morphine and codeine skeletons. Lycorine also has antiarrhythmic action, and lycorine hydrochloride is a strong broncholytic. In fact, lycorine shows a relaxant effect on an isolated epinephrine-precontracted pulmonary artery and increases contractility and the rate of an isolated perfused heart. These effects are mediated by stimulation of b-adrenergic receptors.Lycorine also has a strong inhibitory effect on parasite (Encephalitozoon intestinalis) development and antifungal activity against Candida albicans. Additionally, lycorine has antifeedant, antimalarial, emetic, anti-inflammatory, antiplatelet , as well as antifertility activities. Galanthine, in turn, shows mild in vitro activity against Tripanosoma brucei rhodesiense and Plasmodium falciparum.