MK-2048
MK-2048
- CAS:
- 869901-69-9
- MF:
- C21H21ClFN5O4
- MW:
- 461.87
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Properties
- Density
- 1.55
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO > 10 mM
- form
- Powder
- pka
- 6.30±0.40(Predicted)
- color
- Light yellow to yellow
Safety Information
Use
MK-2048 represents a prototype second generation integrase strand transfer inhibitor (INSTI), it was developed with the goal of retaining activity against viruses containing mutations assiciated with resistance of first-generation INSTIs, raltegravir (R100312). MK-2048 exhibits inhibitory activity towards HIV integrase and towards HIV replication. It is four times more effective in inhibiting HIV enzyme integrase than the first generation inhibitor, raltegravir.
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