Nateglinide
Nateglinide
- CAS:
- 105816-04-4
- MF:
- C19H27NO3
- MW:
- 317.42
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Company Type
Properties
- Melting point:
- 137-141°C
- alpha
- D20 -9.4° (c = 1 in methanol)
- Boiling point:
- 527.6±39.0 °C(Predicted)
- Density
- 1.104±0.06 g/cm3(Predicted)
- storage temp.
- room temp
- solubility
- DMSO: >5mg/mL
- form
- solid
- pka
- 3.61±0.10(Predicted)
- color
- white to off-white
- Merck
- 14,6428
Safety Information
- Symbol(GHS)
GHS07,GHS08
- Signal word
- Warning
- Hazard statements
- H361
- Precautionary statements
- P201-P202-P281-P308+P313-P405-P501
- Hazard Codes
- Xn
- Risk Statements
- 22
- Safety Statements
- 24/25-36
- WGK Germany
- 3
- RTECS
- SQ7318950
- HS Code
- 29242990
- Toxicity
- LD50 orally in rats: >2.0 g/kg (Hasegawa)
Use
Nateglinide is a N-acylated D-phenylalanine marketed in Japan as novel orally active insulinotropic agent for the treatment of type-2 diabetes mellitus. It belongs to the class of nonsulfonylureas and shows some structural similarity to repaglinide, the only other representative in this family. In single pancreatic beta-cells isolated from rats, Nateglinide was found to specifically block the ATP-sensitive K+ channel resulting in an increase in intracellular calcium concentration. This primary action would underlie the mechanism by which Nateglinide markedly stimulates or potentiates, depending on glucose concentrations, insulin secretion from pancreatic beta-cells. Clinical studies demonstrated a good safety profile with a low potential for hypoglycemia.
58 India supplier list of "Nateglinide"
- Product Name:Nateglinide
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg
- Company Type: Manufacturer
- Country/Region: Gujarat,INDIA
- Product Name:Nateglinide
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Gujarat,INDIA
- Product Name:Nateglinide HCI
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Ahmedabad,INDIA
- Product Name:Nateglinide
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: New Delhi,INDIA
- Product Name:Nateglinide
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg And 1MT
- Company Type: Manufacturer
- Country/Region: Maharashtra,INDIA
- Product Name:Nateglinide
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Gujarat,INDIA
- Product Name:Nateglinide (2R)-2-({[trans-4-(1-methylethyl)cyclohexyl]carbonyl}amino)-3- phenylpropanoic acid
- Products Intro:Purity: 96% | Package: 25 mg, 50 mg , 100mg or 500 mg
- Company Type: Manufacturer
- Country/Region: Maharashtra,INDIA
- Product Name:Nateglinide
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg And 1MT
- Company Type: Manufacturer
- Country/Region: Telangana,INDIA
- Product Name:Nateglinide
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg And 1MT
- Company Type: Manufacturer
- Country/Region: Maharashtra,INDIA
- Product Name:Nateglinide
- Products Intro:Brand:sigma aldrich | Product Number:N3538 | Purity:≥98%(HPLC),solid
- Company Type: Trader
- Country/Region: Bangalore,INDIA