Tenofovir
Tenofovir
- CAS:
- 147127-20-6
- MF:
- C9H14N5O4P
- MW:
- 287.21
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Properties
- Melting point:
- 276-280°C
- alpha
- D +21° (c = 1 in 0.1M HCl)
- Boiling point:
- 616.1±65.0 °C(Predicted)
- Density
- 1.79±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Aqueous Acid (Sparingly), DMSO (Slightly, Heated), Water (Slightly, Heated)
- pka
- 2.36±0.10(Predicted)
- form
- powder
- color
- white to beige
- optical activity
- [α]/D -20 to -26°, c = 0.5 in 1 M HCl
- Water Solubility
- 13.4 mg/mL (25 ºC)
- Merck
- 14,9146
- InChI
- InChI=1S/C9H14N5O4P/c1-6(18-5-19(15,16)17)2-14-4-13-7-8(10)11-3-12-9(7)14/h3-4,6H,2,5H2,1H3,(H2,10,11,12)(H2,15,16,17)/t6-/m1/s1
- InChIKey
- SGOIRFVFHAKUTI-ZCFIWIBFSA-N
- SMILES
- P(CO[C@H](C)CN1C2C(N=C1)=C(N)N=CN=2)(=O)(O)O
- CAS DataBase Reference
- 147127-20-6(CAS DataBase Reference)
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H302-H315-H319-H332-H335
- Precautionary statements
- P261-P280-P305+P351+P338
- RTECS
- SZ6563600
- HS Code
- 29339900
Use
Tenofovir disoproxil is an acyclic nucleoside antivirus drug and has an inhibiting effect on HBV multi-enzyme complexes and HIV reverse transcriptase. Its active content tenofovir phosphonate directly competitively binds to natural deoxyribose substrate to inhibit the virus multi-enzyme complex and inserts itself into the DNA to end the nucleotide chain. Tenofovir disoproxil is barely absorbed by the gastrointestinal duct, so it undergoes esterification and ionization to become tenofovir ester fumarate. Tenofovir is soluble in water and can be quickly absorbed and decomposed into the active substance tenofovir, which then transforms into the active metabolite tenofovir phosphonate. As this drug is not metabolized by the CYP450 enzyme system, it has a very low chance of drug interactions caused by this enzyme.
24 India supplier list of "Tenofovir"
- Product Name:Tenofovir
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg
- Company Type: Reagent
- Country/Region: Telangana,INDIA
- Product Name:Tenofovir
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Karnataka,INDIA
- Product Name:Tenofovir
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Gujarat,INDIA
- Product Name:Tenofovir
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg And 1MT
- Company Type: Manufacturer
- Country/Region: Telangana,INDIA
- Product Name:Tenofovir
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Telangana,INDIA
- Product Name:Tenofovir
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Telangana,INDIA
- Product Name:Tenofovir
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Telangana,INDIA
- Product Name:(R)-9-[2-(Phosphonomethoxy)propyl]adenine (PMPA)
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Telangana,INDIA
- Product Name:(R)-(1-(6-amino-9H-purin-9-yl)propan-2-yloxy)methylphosphonic acid hydrate
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Trader
- Country/Region: Hyderabad,INDIA
- Product Name:(R)-[[2-(6-amino-9H-purin-9-yl)-1-methylethoxy] methyl] phosphonic acid (PMPA)
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Hyderabad,INDIA