Vincristine sulfate
Vincristine sulfate
- CAS:
- 2068-78-2
- MF:
- C46H58N4O14S
- MW:
- 923.04
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Company Type
Properties
- Melting point:
- 300 °C
- Boiling point:
- 273-281 °C
- alpha
- D26 +8.5° (c = 0.8)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- methanol: soluble20mg/mL
- form
- lyophilized powder
- color
- white to off-white
- Water Solubility
- >=1 g/100 mL at 24 ºC
- BRN
- 3924631
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.
- InChIKey
- AQTQHPDCURKLKT-HSMPTBRCNA-N
Safety Information
- Symbol(GHS)
GHS06,GHS08
- Signal word
- Danger
- Hazard statements
- H300-H341-H361fd
- Precautionary statements
- P202-P264-P270-P280-P301+P310-P405
- Hazard Codes
- T
- Risk Statements
- 61-36/37/38-63-23/24/25-68-62-25
- Safety Statements
- 22-24/25-53-45-37/39-26-36/37/39-36/37
- RIDADR
- UN 2811 6.1/PG 2
- WGK Germany
- 3
- RTECS
- OH6340000
- F
- 8-10
- HazardClass
- 6.1(a)
- PackingGroup
- II
- HS Code
- 29399990
- Toxicity
- LD50 intraperitoneal in mouse: 3mg/kg
Use
Vincristine sulfate is available as a 1-mg/mL solution in 1-,2-, and 5-mL vials for IV administration in acute leukemiaand as part of a multidrug regime for Hodgkin’s and neuroblastoma, Ewing sarcoma, Wilms tumor, soft tissuesarcoma, testicular cancer, liver cancer, and head and neckcancers. It has also been utilized in treating pediatric cancer.Vincristine is highly protein bound (75%) and may also bindto platelets that contain large amounts of tubulin. Numerousmetabolites have been detected and several have been identified,one of which is the 4-O-desacetyl derivative. The metabolismthat does occur is believed to largely be mediatedby CYP3A. Elimination occurs primarily in the bile with aterminal elimination half-life of 23 to 85 hours. The mostcommonly seen toxicity for vincristine is a dose-limitingneurotoxicity caused by effects on axonal microtubules.Symptoms are variable and include peripheral neuropathy,ataxia, seizure, bone pain, and coma. Constipation is also acommonly seen toxicity, and laxatives may be used prophylactically.Other toxicities include alopecia, skin rash, mildmyelosuppression, secretion of antidiuretic hormone,azospermia, and amenorrhea.
9 India supplier list of "Vincristine sulfate"
![](/images/pro-3.jpg)
- Product Name:Vincristine sulfate
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: INDIA
![](/images/pro-3.jpg)
- Product Name:Vincristine sulfate
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: INDIA
![](/images/pro-3.jpg)
- Product Name:Vincristine sulfate
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg And 1MT
- Company Type: Manufacturer
- Country/Region: INDIA
![](/images/pro-3.jpg)
- Product Name:VincristineSulfate,Apocynaceaesp.-CAS2068-78-2-Calbiochem
- Products Intro:Brand:sigma aldrich | Product Number:677181 | Purity:Indolealkaloidthatbindstotubulin,inhibitingformationofmicrotubules.
- Company Type: Trader
- Country/Region: INDIA
![](/images/pro-3.jpg)
- Product Name:VincristineSulfate
- Products Intro:Brand:synzeal | Product Number:201073843
- Company Type: Trader
- Country/Region: INDIA