Y320
Y320
- CAS:
- 288250-47-5
- MF:
- C27H29ClN6O2
- MW:
- 505.01
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Properties
- Boiling point:
- 631.2±55.0 °C(Predicted)
- Density
- 1.34±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- ≥24.8 mg/mL in DMSO with gentle warming; insoluble in H2O; insoluble in EtOH
- form
- solid
- pka
- 11.82±0.70(Predicted)
- color
- Off-white to pink
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H315-H319
- Precautionary statements
- P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362
Use
Y-320 (0.3-3 mg/kg p.o.) ameliorates collagen-induced arthritis (CIA) in Mice with a reduction of IL-17 mRNA in arthritic joints, and also shows therapeutic effects on CIA in cynomolgus monkeys. Moreover, Y-320 shows a synergistic effect in combination with anti-TNF-α mAb on chronic-progressing CIA in mice.
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