YK-4-279
YK-4-279
- CAS:
- 1037184-44-3
- MF:
- C17H13Cl2NO4
- MW:
- 366.2
Suppliers by country/region
Company Type
Properties
- Melting point:
- 149-151℃
- Boiling point:
- 608.9±55.0 °C(Predicted)
- Density
- 1.456
- storage temp.
- Store at -20° C.
- solubility
- insoluble in H2O; ≥16.35 mg/mL in DMSO; ≥24.25 mg/mL in EtOH with ultrasonic
- form
- Powder
- pka
- 10.43±0.20(Predicted)
- color
- White to off-white
Safety Information
Use
An oncogenic fusion protein found in Ewing's sarcoma, a family of undifferentiated tumors which occur throughout the body. The binding of ES-FLI1 to RNA helicase A (RHA) promotes its oncogenic function. Inhibits protein-protein interactions between ES-FLI1 and RHA. At 10 μM, YK-4-279 blocks RHA binding to ES-FLI1 and induces apoptosis of a panel of Ewing's sarcoma tumor cell lines with IC50 values ranging from 0.5 to 2 μM.1 At 1.5 mg per dose, YK-4-279 reduces the growth of Ewing's sarcoma orthotopic xenografts in mice after treatment with the inhibitor for two weeks.
1 India supplier list of "YK-4-279"
- Product Name:YK-4-279 >95%
- Products Intro:Brand：Glrinnovations | OriginalID：GLR19.089903
- Company Type: Trader
- Country/Region: INDIA
- Product Name:YK-4-279
- Products Intro:Purity: 98% | Package: 10MG;50MG;100MG,1G,5G,10G.100G
- Company Type: Reagent
- Country/Region: CHINA
- Product Name:4,7-dichloro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-1H-indol-2-one
- Products Intro:Purity: Min98% HPLC | Package: 1KG;1USD
- Company Type: Trader
- Country/Region: CHINA
$1.00/ 1KG
- Product Name:YK-4-279
- Products Intro:Purity: 98% | Package: Package as requetsed
- Company Type: Trader
- Country/Region: CHINA
- Product Name:YK-4-279
- Products Intro:Purity: 99.89% | Package: 1 mL * 10mM (in DMSO)；10 mg；100 mg；200 mg；25 mg；5 mg；50 mg | CustNote: REAGENT;FOR LABORATORY USE ONLY
- Company Type: Trader
- Country/Region: UNITED STATES
- Product Name:YK-4-279
- Products Intro:Purity: 99.9% | Package: 25kgs/Drum;200kgs/Drum | CustNote: FDA GMP CEP Approved Manufacturer
- Company Type: Trader
- Country/Region: CHINA
- Product Name:yk-4-279
- Products Intro:Purity: 99% | Package: 5KG;1KG | CustNote: yk-4-279
- Company Type: Trader
- Country/Region: CHINA
- Product Name:YK 4-279
- Products Intro:Package: 1g; 5g; 25g; 1kg; 5kg; 25kg
- Company Type: Trader
- Country/Region: CHINA
- Product Name:YK-4-279
- Products Intro:Purity: 98% | Package: 50mg, 100mg, 10mg, 5mg
- Company Type: Trader
- Country/Region: CHINA
- Product Name:YK-4-279
- Products Intro:Purity: >=98% | Package: $65.9/5mg;$103.9/10mg;$401.9/50mg;$737.9/100mg;Bulk package | CustNote: 98%
- Company Type: Trader
- Country/Region: UNITED STATES