Cyclosporin A suppliers
Cyclosporin A
- CAS:
- 59865-13-3
- MF:
- C62H111N11O12
- MW:
- 1202.61
Suppliers by country/region
Company Type
Properties
- Melting point:
- 148-151°C
- alpha
- D20 -244° (c = 0.6 in chloroform); D20 -189° (c = 0.5 in methanol)
- Boiling point:
- 838.63°C (rough estimate)
- Density
- 0.9913 (rough estimate)
- refractive index
- 1.6500 (estimate)
- Flash point:
- 87℃
- storage temp.
- -20°C
- solubility
- ethanol: 30 mg/mL
- form
- solid
- pka
- 13.32±0.70(Predicted)
- color
- white
- Water Solubility
- Soluble in dimethyl sulfoxide and ethanol. Insoluble in water.
- Merck
- 14,2752
- BRN
- 3647785
- Stability:
- Stable for 3 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
- InChIKey
- PMATZTZNYRCHOR-CGLBZJNRSA-N
Safety Information
- Symbol(GHS)
GHS07,GHS08
- Signal word
- Danger
- Hazard statements
- H302-H350-H360FD
- Precautionary statements
- P201-P202-P264-P270-P301+P312-P308+P313
- Hazard Codes
- T,Xn,F
- Risk Statements
- 45-60-22-40-36-20/21/22-11
- Safety Statements
- 53-45-36/37-24/25-22-26-16
- RIDADR
- UN 1648 3 / PGII
- WGK Germany
- 3
- RTECS
- GZ4120000
- HS Code
- 29419090
- Toxicity
- LD50 in mice, rats, rabbits (mg/kg): 107, 25, >10 i.v.; 2329, 1480, >1000 orally (Ryffel)
Use
Cyclosporin A is a hydrophobic cyclic peptide isolated from several fungal species including Cylindrocarpon, Fusarium, Trichoderma and Tolypocladium. Cyclosporin A inhibits T-cell activation and has been marketed since 1983 as an immunosuppressant in post-allogeneic organ transplant. Cyclosporin A acts by binding to the protein, cyclophilin (immunophilin), in T-lymphocytes causing inhibition of calcineurin (protein phosphatase 2B). Cyclosporin A reduces transcription of interleukin 2, and inhibits lymphokine production, interleukin release and NO synthesis induced by interleukin 1α, lipopolysaccharides and TNFα.
470 supplier list of "Cyclosporin A"
- Product Name:Cyclosporin A
- Products Intro:Purity: 0.99 | Package: 1G；100G;1KG
- Company Type: Trader
- Country/Region: CHINA
- Main Products: 1,4-Naphthalenedicarboxylic acid,Pamoic acid,Enfumafungin,6-bromonaphthalen-2-amine,Fusidic acid
$9.00-70.00 / 10g
- Product Name:Cyclosporin A
- Products Intro:Purity: 99% | Package: 10g;9USD|100g;70USD
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Tianeptine sodium salt hydrate,Tianeptine sulfate,Tianeptine,Tadalafil,Lubricant oil
$0.00/ 1kg
- Product Name:Cyclosporin A
- Products Intro:Purity: 99%|Package: 1kg;0.00;USD
- Company Type: Trader
- Country/Region: CHINA
- Product Name:Cyclosporin A
- Products Intro:Purity: 98% Min. | Package: 1G;1KG;100KG
- Company Type: Trader
- Country/Region: CHINA
- Main Products: 1159983-30-8,89466-59-1,149739-51-5,104901-79-3,10541-83-0
- Product Name:Cyclosporin A
- Products Intro:Purity: 99% | Package: 25KG;5KG;1KG
- Company Type: Trader
- Country/Region: CHINA
- Product Name:Cyclosporin A
- Products Intro:Purity: 98% | Package: 10MG;50MG;100MG,1G,5G,10G.100G
- Company Type: Reagent
- Country/Region: CHINA
$1.00/ 1KG
- Product Name:Cyclosporin A
- Products Intro:Purity: 98% | Package: 1KG;1USD
- Company Type: Reagent
- Country/Region: CHINA
- Main Products: Nicotinamide riboside chloride,Curcumin,L(+)-Ascorbic acid,L-Glutamine,Stevioside Basic information
- Product Name:Cyclosporin A
- Products Intro:Purity: 0.99 | Package: 5KG;1KG
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Daily Chemicals
- Product Name:Ciclosporin
- Products Intro:Purity: 99% | Package: 200kg/drum
- Company Type: Service provider
- Country/Region: CHINA
- Main Products: UDDA
- Product Name:Cyclosporin A
- Products Intro:Purity: 0.99 | Package: 1g;25g;1kg;25kg;100kg
- Company Type: Trader
- Country/Region: CHINA