BISINDOLYLMALEIMIDE I HYDROCHLORIDE
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- $32 - $986.15
- Product name: BISINDOLYLMALEIMIDE I HYDROCHLORIDE
- CAS: 176504-36-2
- MF: C25H25ClN4O2
- MW: 448.95
- EINECS:
- MDL Number:MFCD00236429
- Synonyms:BIM 1 hydrochloride;3-[1-(dimethylaminopropyl)indol-3-yl]-4-(indol-3-yl)maleimide hydrochloride;BisindolylMaleiMide I( Hydrochloride Salt);BisindolylMaleiMide I . hydrochloride [GF-109203K;3-[1-[3-(Dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione monohydrochloride;3-[1-[3-(dimethylamino)propyl]indol-3-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dione;Bisindolylmaleimide I, Hydrochloride - CAS 176504-36-2 - Calbiochem;GF 109203X hydrochloride >=95%
12 prices
Selected condition：
Brand
- Adipogen Life Sciences
- AK Scientific
- American Custom Chemicals Corporation
- Cayman Chemical
- Sigma-Aldrich
Package
- 250ug
- 250μg
- 500μg
- 1mg
- 5MG
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-0110-M001
- Product descriptionBisindolylmaleimide I, Hydrochloride ≥98%(NMR)
- Packaging1mg
- Price$55
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number8103CP
- Product descriptionBisindolylmaleimideI,HCl
- Packaging1mg
- Price$154
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000053
- Product descriptionBISINDOLYLMALEIMIDE I HYDROCHLORIDE 95.00%
- Packaging1MG
- Price$498
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000053
- Product descriptionBISINDOLYLMALEIMIDE I HYDROCHLORIDE 95.00%
- Packaging5MG
- Price$986.15
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number21180
- Product descriptionBisindolylmaleimide I (hydrochloride) ≥98%
- Packaging500μg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number21180
- Product descriptionBisindolylmaleimide I (hydrochloride) ≥98%
- Packaging1mg
- Price$50
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number21180
- Product descriptionBisindolylmaleimide I (hydrochloride) ≥98%
- Packaging5mg
- Price$158
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product number203291
- Product descriptionBisindolylmaleimide I, Hydrochloride An enhanced water-soluble form of Bisindolylmaleimide I.
- Packaging250ug
- Price$65.2
- Updated2021-12-16
- Buy
- ManufacturerSigma-Aldrich
- Product number203291
- Product descriptionBisindolylmaleimide I, Hydrochloride - CAS 176504-36-2 - Calbiochem An enhanced water-soluble form of Bisindolylmaleimide I.
- Packaging250μg
- Price$68.9
- Updated2023-06-20
- Buy
- ManufacturerSigma-Aldrich
- Product numberB6292
- Product descriptionGF 109203X hydrochloride ≥95%
- Packaging250μg
- Price$80.7
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product number203291
- Product descriptionBisindolylmaleimide I, Hydrochloride An enhanced water-soluble form of Bisindolylmaleimide I.
- Packaging1mg
- Price$187
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product numberB6292
- Product descriptionGF 109203X hydrochloride ≥95%
- Packaging1mg
- Price$221
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | AG-CR1-0110-M001 | Bisindolylmaleimide I, Hydrochloride ≥98%(NMR) | 1mg | $55 | 2021-12-16 | Buy |
| AK Scientific | 8103CP | BisindolylmaleimideI,HCl | 1mg | $154 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000053 | BISINDOLYLMALEIMIDE I HYDROCHLORIDE 95.00% | 1MG | $498 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000053 | BISINDOLYLMALEIMIDE I HYDROCHLORIDE 95.00% | 5MG | $986.15 | 2021-12-16 | Buy |
| Cayman Chemical | 21180 | Bisindolylmaleimide I (hydrochloride) ≥98% | 500μg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 21180 | Bisindolylmaleimide I (hydrochloride) ≥98% | 1mg | $50 | 2024-03-01 | Buy |
| Cayman Chemical | 21180 | Bisindolylmaleimide I (hydrochloride) ≥98% | 5mg | $158 | 2024-03-01 | Buy |
| Sigma-Aldrich | 203291 | Bisindolylmaleimide I, Hydrochloride An enhanced water-soluble form of Bisindolylmaleimide I. | 250ug | $65.2 | 2021-12-16 | Buy |
| Sigma-Aldrich | 203291 | Bisindolylmaleimide I, Hydrochloride - CAS 176504-36-2 - Calbiochem An enhanced water-soluble form of Bisindolylmaleimide I. | 250μg | $68.9 | 2023-06-20 | Buy |
| Sigma-Aldrich | B6292 | GF 109203X hydrochloride ≥95% | 250μg | $80.7 | 2024-03-01 | Buy |
| Sigma-Aldrich | 203291 | Bisindolylmaleimide I, Hydrochloride An enhanced water-soluble form of Bisindolylmaleimide I. | 1mg | $187 | 2024-03-01 | Buy |
| Sigma-Aldrich | B6292 | GF 109203X hydrochloride ≥95% | 1mg | $221 | 2024-03-01 | Buy |
Properties
storage temp. :2-8°C
solubility :DMF: 10 mg/mL; DMSO: 16 mg/mL; DMSO:PBS(pH 7.2) (1:4): 0.2 mg/mL
form :Orange-red solid
color :Orange to red
solubility :DMF: 10 mg/mL; DMSO: 16 mg/mL; DMSO:PBS(pH 7.2) (1:4): 0.2 mg/mL
form :Orange-red solid
color :Orange to red
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
Bisindolylmaleimide I (BIM I) is a highly selective, cell-permeable, and reversible PKC inhibitor (Ki = 14 nM) that is structurally similar to the poorly selective PKC inhibitor staurosporine . It acts as a competitive inhibitor for the ATP binding site of PKC and shows high selectivity for PKCα, β1, β2, γ, δ, and ε isozymes. BIM I directly inhibits glycogen synthase kinase 3 (GSK3) in primary adipocyte lysates (IC50 = 360 nM) and in GSK3β immunoprecipitates derived from rat epididymal adipocytes (IC50 = 170 nM). It also competitively antagonizes the serotonin (5-HT) receptor subtype 5-HT3 with a Ki value of 61 nM.More related product prices
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