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ChemicalBook >> CAS DataBase List >> α,α-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile

α,α-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile

$32 - $2839
Product name: α,α-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile
CAS: 218136-59-5
MF: C27H29N5
MW: 423.55
EINECS:
MDL Number:MFCD11226148
Synonyms:SC 26196;α,α-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile;alpha,alpha-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile;α,α-Diphenyl-4-[(3-pyridinylMethylene)aMino]-1-piperazine;2,2-diphenyl-5-{4-[(E)-(pyridin-3-ylMethylidene)aMino]piperazin-1-yl}pentanenitrile;PF-o6341724;(E)-2,2-diphenyl-5-(4-((pyridin-3-ylMethylene)aMino)piperazin-1-yl)pentanenitrile;2,2-diphenyl-5-(4-[[(1 E)-pyridin-3-yl-methylidene]amino]piperazin-1-yl)pentanenitrile

Price23 Properties Safety Information Description

23 prices

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Brand

American Custom Chemicals Corporation
ApexBio Technology
Axon Medchem
Biorbyt Ltd
Cayman Chemical
CSNpharm
DC Chemicals
Medical Isotopes, Inc.
Sigma-Aldrich
Tocris
TRC
Usbiological

Package

50
10
1mg
5MG
10MG
25mg
50mg
100MG
250mg
1g
1000mg

ManufacturerAmerican Custom Chemicals Corporation
Product numberAPI0010312
Product descriptionALPHA,ALPHA-DIPHENYL-4-[(3-PYRIDINYLMETHYLENE)AMINO]-1-PIPERAZINEPENTANENITRILE 95.00%
Packaging5MG
Price$242
Updated2021-12-16
Buy

ManufacturerAmerican Custom Chemicals Corporation
Product numberAPI0010312
Product descriptionALPHA,ALPHA-DIPHENYL-4-[(3-PYRIDINYLMETHYLENE)AMINO]-1-PIPERAZINEPENTANENITRILE 95.00%
Packaging10MG
Price$716.1
Updated2021-12-16
Buy

ManufacturerAmerican Custom Chemicals Corporation
Product numberAPI0010312
Product descriptionALPHA,ALPHA-DIPHENYL-4-[(3-PYRIDINYLMETHYLENE)AMINO]-1-PIPERAZINEPENTANENITRILE 95.00%
Packaging100MG
Price$1686.3
Updated2021-12-16
Buy

ManufacturerApexBio Technology
Product numberB7608
Product descriptionSC26196
Packaging10mg
Price$202
Updated2021-12-16
Buy

ManufacturerApexBio Technology
Product numberB7608
Product descriptionSC26196
Packaging50mg
Price$852
Updated2021-12-16
Buy

ManufacturerAxon Medchem
Product numberAxon2112
Product descriptionSC26196-PF06341724 99%
Packaging25mg
Price$313.5
Updated2021-12-16
Buy

ManufacturerBiorbyt Ltd
Product numberorb180842
Product descriptionSC-26196 >98%
Packaging100mg
Price$838.1
Updated2021-12-16
Buy

ManufacturerBiorbyt Ltd
Product numberorb180842
Product descriptionSC-26196 >98%
Packaging250mg
Price$1504.5
Updated2021-12-16
Buy

ManufacturerBiorbyt Ltd
Product numberorb180842
Product descriptionSC-26196 >98%
Packaging1000mg
Price$2839
Updated2021-12-16
Buy

ManufacturerCayman Chemical
Product number10792
Product descriptionSC 26196 ≥98%
Packaging1mg
Price$32
Updated2024-03-01
Buy

ManufacturerCayman Chemical
Product number10792
Product descriptionSC 26196 ≥98%
Packaging5mg
Price$122
Updated2024-03-01
Buy

ManufacturerCayman Chemical
Product number10792
Product descriptionSC 26196 ≥98%
Packaging10mg
Price$169
Updated2024-03-01
Buy

ManufacturerCayman Chemical
Product number10792
Product descriptionSC 26196 ≥98%
Packaging25mg
Price$381
Updated2024-03-01
Buy

ManufacturerCSNpharm
Product numberCSN26132
Product descriptionSC-26196
Packaging50mg
Price$656
Updated2021-12-16
Buy

ManufacturerDC Chemicals
Product numberDC7029
Product descriptionSC-26196 >98%
Packaging100mg
Price$550
Updated2021-12-16
Buy

ManufacturerDC Chemicals
Product numberDC7029
Product descriptionSC-26196 >98%
Packaging1g
Price$1900
Updated2021-12-16
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
American Custom Chemicals Corporation	API0010312	ALPHA,ALPHA-DIPHENYL-4-[(3-PYRIDINYLMETHYLENE)AMINO]-1-PIPERAZINEPENTANENITRILE 95.00%	5MG	$242	2021-12-16	Buy
American Custom Chemicals Corporation	API0010312	ALPHA,ALPHA-DIPHENYL-4-[(3-PYRIDINYLMETHYLENE)AMINO]-1-PIPERAZINEPENTANENITRILE 95.00%	10MG	$716.1	2021-12-16	Buy
American Custom Chemicals Corporation	API0010312	ALPHA,ALPHA-DIPHENYL-4-[(3-PYRIDINYLMETHYLENE)AMINO]-1-PIPERAZINEPENTANENITRILE 95.00%	100MG	$1686.3	2021-12-16	Buy
ApexBio Technology	B7608	SC26196	10mg	$202	2021-12-16	Buy
ApexBio Technology	B7608	SC26196	50mg	$852	2021-12-16	Buy
Axon Medchem	Axon2112	SC26196-PF06341724 99%	25mg	$313.5	2021-12-16	Buy
Biorbyt Ltd	orb180842	SC-26196 >98%	100mg	$838.1	2021-12-16	Buy
Biorbyt Ltd	orb180842	SC-26196 >98%	250mg	$1504.5	2021-12-16	Buy
Biorbyt Ltd	orb180842	SC-26196 >98%	1000mg	$2839	2021-12-16	Buy
Cayman Chemical	10792	SC 26196 ≥98%	1mg	$32	2024-03-01	Buy
Cayman Chemical	10792	SC 26196 ≥98%	5mg	$122	2024-03-01	Buy
Cayman Chemical	10792	SC 26196 ≥98%	10mg	$169	2024-03-01	Buy
Cayman Chemical	10792	SC 26196 ≥98%	25mg	$381	2024-03-01	Buy
CSNpharm	CSN26132	SC-26196	50mg	$656	2021-12-16	Buy
DC Chemicals	DC7029	SC-26196 >98%	100mg	$550	2021-12-16	Buy
DC Chemicals	DC7029	SC-26196 >98%	1g	$1900	2021-12-16	Buy

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Properties

storage temp. :2-8°C
solubility :DMSO: ≥10mg/mL
form :powder
color :white to tan

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	P-Codes
H302	Harmful if swallowed	Acute toxicity,oral	Category 4	Warning	P264, P270, P301+P312, P330, P501
H315	Causes skin irritation	Skin corrosion/irritation	Category 2	Warning	P264, P280, P302+P352, P321,P332+P313, P362
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning	P264, P280, P305+P351+P338,P337+P313P
H335	May cause respiratory irritation	Specific target organ toxicity, single exposure;Respiratory tract irritation	Category 3	Warning

Precautionary statements:

P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352	IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

SC 26196 is an inhibitor of Δ6 desaturase (IC50 = 0.2 μM in a rat liver microsomal assay) that completely blocks the conversion of linoleic acid to arachidonic acid (AA). It is selective for Δ6 desaturase, as IC50 values for Δ5 and Δ9 desaturases exceed 200 μM and it has no effect on the conversion of dihomo-γ-linolenic acid to AA. SC 26196 is orally active in vivo, decreasing edema in the carrageenan paw edema model in mice. It also blocks aging-related increases in AA in myocardial cardiolipin in mice, attenuating contractile dysfunction without impacting mitochondrial oxidative stress.

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