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ChemicalBook >> CAS DataBase List >> BI-D1870

BI-D1870

BI-D1870 price.
  • $56 - $4966.5
  • Product name: BI-D1870
  • CAS: 501437-28-1
  • MF: C19H23F2N5O2
  • MW: 391.42
  • EINECS:
  • MDL Number:MFCD11223662
  • Synonyms:BI-D1870;2-[(3,5-difluoro-4-hydroxyphenyl)aMino]-5,7-diMethyl-8-(3-Methylbutyl)-5,6,7,8-tetrahydropteridin-6-one;6(5H)-Pteridinone, 2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7,8-dihydro-5,7-dimethyl-8-(3-methylbutyl)-;2-[(3,5-DIFLUORO-4-HYDROXYPHENYL)AMINO]-7,8-DIHYDRO-5,7-DIMETHYL-8-(3-METHYLBUTYL)-6(5H)-PTERIDINONE;2-(3,5-Difluoro-4-hydroxyphenylamino)-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydro-5H-pteridin-6-one;CS-606;BID1870;BI-D 1870;BI-D1870 USP/EP/BP
Price29 Properties Safety Information Description
29 prices
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Brand
  • Adipogen Life Sciences
  • AK Scientific
  • Alfa Aesar
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Axon Medchem
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • SynChem
  • TRC
Package
  • 1mg
  • 2mg
  • 2.5mg
  • 5mg
  • 10mg
  • 25mg
  • 10mM(in 1mL DMSO)
  • 50mg
  • 100mg
  • 250mg
  • 500mg
  • 1000mg
  • 5G
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1020-M005
  • Product descriptionBI-D1870 ≥95%
  • Packaging5mg
  • Price$184
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberSYN1020
  • Product descriptionBI-D1870
  • Packaging5mg
  • Price$190
  • Updated2021-12-16
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ67102
  • Product descriptionBI-D1870, 98%
  • Packaging1mg
  • Price$77.8
  • Updated2021-12-16
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ67102
  • Product descriptionBI-D1870, 98%
  • Packaging5mg
  • Price$264
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000051
  • Product descriptionBI-D1870 95.00%
  • Packaging5G
  • Price$4966.5
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB2227
  • Product descriptionBI-D1870
  • Packaging5mg
  • Price$120
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB2227
  • Product descriptionBI-D1870
  • Packaging10mM(in 1mL DMSO)
  • Price$160
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB2227
  • Product descriptionBI-D1870
  • Packaging10mg
  • Price$190
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB2227
  • Product descriptionBI-D1870
  • Packaging50mg
  • Price$470
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60349
  • Product descriptionBI-D1870 ≥98%
  • Packaging10mg
  • Price$448
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon1528
  • Product descriptionBI-D1870 99%
  • Packaging25mg
  • Price$401.5
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180955
  • Product descriptionBI-D1870 >98%
  • Packaging100mg
  • Price$986
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180955
  • Product descriptionBI-D1870 >98%
  • Packaging250mg
  • Price$1802
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180955
  • Product descriptionBI-D1870 >98%
  • Packaging1000mg
  • Price$3728.1
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD102472
  • Product descriptionBI-D1870
  • Packaging10mg
  • Price$225
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD102472
  • Product descriptionBI-D1870
  • Packaging50mg
  • Price$787.5
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences SYN-1020-M005 BI-D1870 ≥95% 5mg $184 2021-12-16 Buy
AK Scientific SYN1020 BI-D1870 5mg $190 2021-12-16 Buy
Alfa Aesar J67102 BI-D1870, 98% 1mg $77.8 2021-12-16 Buy
Alfa Aesar J67102 BI-D1870, 98% 5mg $264 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000051 BI-D1870 95.00% 5G $4966.5 2021-12-16 Buy
ApexBio Technology B2227 BI-D1870 5mg $120 2021-12-16 Buy
ApexBio Technology B2227 BI-D1870 10mM(in 1mL DMSO) $160 2021-12-16 Buy
ApexBio Technology B2227 BI-D1870 10mg $190 2021-12-16 Buy
ApexBio Technology B2227 BI-D1870 50mg $470 2021-12-16 Buy
Arctom CFN60349 BI-D1870 ≥98% 10mg $448 2021-12-16 Buy
Axon Medchem Axon1528 BI-D1870 99% 25mg $401.5 2021-12-16 Buy
Biorbyt Ltd orb180955 BI-D1870 >98% 100mg $986 2021-12-16 Buy
Biorbyt Ltd orb180955 BI-D1870 >98% 250mg $1802 2021-12-16 Buy
Biorbyt Ltd orb180955 BI-D1870 >98% 1000mg $3728.1 2021-12-16 Buy
Biosynth Carbosynth FD102472 BI-D1870 10mg $225 2021-12-16 Buy
Biosynth Carbosynth FD102472 BI-D1870 50mg $787.5 2021-12-16 Buy
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Properties

Boiling point :579.3±60.0 °C(Predicted)
Density :1.297
storage temp. :-20°C
solubility :Soluble in DMSO (up to 15 mg/ml)
form :Off-white solid.
pka :7.68±0.36(Predicted)
color :Off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H227 Combustible liquid Flammable liquids Category 4 Warning P210, P280, P370+P378, P403+P235,P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P370+P378 In case of fire: Use … for extinction.
P403+P235 Store in a well-ventilated place. Keep cool.

Description

The 90 kDa ribosomal S6 kinases (RSKs) are a group of serine/threonine kinases involved in diverse cellular processes, including growth, survival, and motility. BI-D1870 is a cell permeable, ATP-competitive inhibitor of the four vertebrate isoforms of RSK, RSK1-4 (IC50s = 31, 24, 18, and 15 nM, respectively). At 100 nM, it also significantly inhibits polo-like kinase 1, Aurora B, maternal embryonic leucine zipper kinase, and mammalian STE20-like kinase 2. BI-D1870 acts at the N-terminal kinase domain, but not the C-terminal domain, of RSK.

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