WYE-354
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- $36 - $1963.5
- Product name: WYE-354
- CAS: 1062169-56-5
- MF: C24H29N7O5
- MW: 495.53
- EINECS:-0
- MDL Number:MFCD18074514
- Synonyms:WYE-354;4-[6-[4-[(Methoxycarbonyl)amino]phenyl]-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinecarboxylic acid methyl ester;methyl 4-[6-[4-(methoxycarbonylamino)phenyl]-4-morpholin-4-ylpyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate;WYE-354 (Degrasyn);WYE-354;WYE 354; WYE354;Methyl 4-(6-(4-(methoxycarbonylamino)phenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pip;CS-441;1-Piperidinecarboxylic acid, 4-[6-[4-[(methoxycarbonyl)amino]phenyl]-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-, methyl ester
38 prices
Selected condition：
Brand
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Sigma-Aldrich
- TRC
Package
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product numberX7422
- Product descriptionmethyl-4-[6-[4-(methoxycarbonylamino)phenyl]-4-morpholin-4-ylpyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate
- Packaging250mg
- Price$1091
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA121661
- Product descriptionWye-354 98+%
- Packaging5mg
- Price$36
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA121661
- Product descriptionWye-354 98+%
- Packaging10mg
- Price$65
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA121661
- Product descriptionWye-354 98+%
- Packaging25mg
- Price$136
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA121661
- Product descriptionWye-354 98+%
- Packaging50mg
- Price$220
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA121661
- Product descriptionWye-354 98+%
- Packaging100mg
- Price$369
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA121661
- Product descriptionWye-354 98+%
- Packaging250mg
- Price$764
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000840
- Product descriptionWYE-354 95.00%
- Packaging5MG
- Price$545
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000840
- Product descriptionWYE-354 95.00%
- Packaging10MG
- Price$750.75
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000840
- Product descriptionWYE-354 95.00%
- Packaging100MG
- Price$1963.5
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1266
- Product descriptionWYE-354
- Packaging5mg
- Price$104
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1266
- Product descriptionWYE-354
- Packaging10mg
- Price$198
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1266
- Product descriptionWYE-354
- Packaging25mg
- Price$469
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1266
- Product descriptionWYE-354
- Packaging50mg
- Price$832
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60432
- Product descriptionWYE-354 ≥98%
- Packaging10mg
- Price$238
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number13604
- Product descriptionWYE-354 ≥98%
- Packaging5mg
- Price$93
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | X7422 | methyl-4-[6-[4-(methoxycarbonylamino)phenyl]-4-morpholin-4-ylpyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate | 250mg | $1091 | 2021-12-16 | Buy |
| Ambeed | A121661 | Wye-354 98+% | 5mg | $36 | 2021-12-16 | Buy |
| Ambeed | A121661 | Wye-354 98+% | 10mg | $65 | 2021-12-16 | Buy |
| Ambeed | A121661 | Wye-354 98+% | 25mg | $136 | 2021-12-16 | Buy |
| Ambeed | A121661 | Wye-354 98+% | 50mg | $220 | 2021-12-16 | Buy |
| Ambeed | A121661 | Wye-354 98+% | 100mg | $369 | 2021-12-16 | Buy |
| Ambeed | A121661 | Wye-354 98+% | 250mg | $764 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000840 | WYE-354 95.00% | 5MG | $545 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000840 | WYE-354 95.00% | 10MG | $750.75 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000840 | WYE-354 95.00% | 100MG | $1963.5 | 2021-12-16 | Buy |
| ApexBio Technology | A1266 | WYE-354 | 5mg | $104 | 2021-12-16 | Buy |
| ApexBio Technology | A1266 | WYE-354 | 10mg | $198 | 2021-12-16 | Buy |
| ApexBio Technology | A1266 | WYE-354 | 25mg | $469 | 2021-12-16 | Buy |
| ApexBio Technology | A1266 | WYE-354 | 50mg | $832 | 2021-12-16 | Buy |
| Arctom | CFN60432 | WYE-354 ≥98% | 10mg | $238 | 2021-12-16 | Buy |
| Cayman Chemical | 13604 | WYE-354 ≥98% | 5mg | $93 | 2024-03-01 | Buy |
Properties
Density :1.46
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :≥49.6 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form :solid
pka :13.42±0.70(Predicted)
color :White to off-white
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :≥49.6 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form :solid
pka :13.42±0.70(Predicted)
color :White to off-white
Safety Information
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Description
WYE-354 is a potent cell-permeable inhibitor of mTOR (IC50 = 4.3 nM) which blocks signaling through both mTOR complex 1 (mTORC1) and mTORC2. It is a much weaker inhibitor of phosphatidylinositol 3-kinase α (IC50 = 1026 nM) and other kinases. WYE-354 induces G1 cell cycle arrest in both rapamycin-sensitive and rapamycin-resistant cancer cell lines, inhibits mTORC1 and mTORC2 in tumor-bearing mice, and reduces tumor growth in nude mice with PTEN-null tumors.Related product price
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