Company Name: |
Wuhan Huangzhen Biochemical Co., Ltd
|
Tel: |
13795480948 13795480948 |
Email: |
3450865996@qq.com |
Products Intro: |
Cas:15307-79-6
ProductName:Diclofenac Sodium Salt
Purity: HPLC>=99% | Package: 100mg
|
Company Name: |
Nanjing Shangshu Biotechnology Co., Ltd
|
Tel: |
18266960953 18266960953 |
Email: |
907697096@qq.com |
Products Intro: |
Cas:15307-79-6
ProductName:Diclofenac Sodium Salt
Purity: HPLC>=98% | Package: 根据客户要求
|
- diclofenac sodium
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- $15.00 / 1KG
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2021-07-09
- CAS:15307-79-6
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
- Diclofenac sodium
-
- $8.00 / 1Kg/Bag
-
2020-11-16
- CAS:15307-79-6
- Min. Order: 1Kg/Bag
- Purity: 99%
- Supply Ability: 20 Tons
Related articles - What is Diclofenac sodium?
- Diclofenac is a phenylacetic acid derivative belonging to the class of the non-selective non-steroidal anti-inflammatory drugs....
- Feb 11,2020
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| Diclofenac Sodium Salt Chemical Properties |
Melting point | 288-290°C | density | 0.781 g/cm3 | storage temp. | room temp | solubility | H2O: 50 mg/mL | form | White solid | pka | 4(at 25℃) | color | White to Almost white | Water Solubility | Soluble in water to 50mg/ml. | Merck | 14,3081 | BCS Class | 2 | Stability: | Stable. | InChI | InChI=1S/C14H11Cl2NO2.Na/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19;/h1-7,17H,8H2,(H,18,19);/q;+1/p-1 | InChIKey | KPHWPUGNDIVLNH-UHFFFAOYSA-M | SMILES | C1(=CC=CC=C1CC([O-])=O)NC1=C(Cl)C=CC=C1Cl.[Na+] | CAS DataBase Reference | 15307-79-6(CAS DataBase Reference) |
Hazard Codes | T,Xi | Risk Statements | 25-36/37/38-63 | Safety Statements | 22-36/37-45-36-26-60-20 | RIDADR | UN 2811 6.1/PG 3 | WGK Germany | 3 | RTECS | AG6330000 | HazardClass | 6.1(b) | PackingGroup | III | HS Code | 29224999 | Toxicity | LD50 in mice, rats (mg/kg): ~390, 150 orally (Krupp) |
| Diclofenac Sodium Salt Usage And Synthesis |
Description |
Diclofenac sodium salt is the sodium salt form of diclofenac, a benzene acetic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with analgesic, antipyretic and anti-inflammatory activity.
| Pharmacology | Diclofenac sodium salt is a non-selective reversible and competitive inhibitor of cyclooxygenase (COX), subsequently blocking the conversion of arachidonic acid into prostaglandin precursors. This leads to an inhibition of the formation of prostaglandins that are involved in pain, inflammation and fever.
| Clinical Use |
Diclofenac sodium salt, like other NSAIDs, is often used as first line therapy for acute and chronic pain and inflammation from a variety of causes. It is often used in combination with misoprostol to prevent NSAID-induced gastric ulcers.
| Side effects | Gastrointestinal problems (ulceration and bleeding) and adverse CNS reactions (dizziness and headache) are the most commonly encountered adverse effects.
| Synthesis |
Acylation of N-phenyl-2,6- dichloroaniline with chloroacetyl chloride gives the corresponding chloroacetanilide, which is fused with aluminum chloride to give 1-(2,6- dichlorophenyl)-2-indolinone. Hydrolysis of the indolinone with dilute aqueous-alcoholic sodium hydroxide affords the desired sodium salt directly.
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| Diclofenac Sodium Salt Preparation Products And Raw materials |
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