克尼托喹
中文名称 | 克尼托喹 |
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中文同义词 | 克尼托喹;氯托喹;去乙基羟基氯喹酸;脱乙基羟基氯喹;去乙基羟基氯喹;去乙基羟氯喹;硫酸羟氯喹EP杂质C(去乙基羟氯喹);硫酸羟氯喹EP杂质C |
英文名称 | DESETHYL HYDROXY CHLOROQUINE |
英文同义词 | 2-[4-[(7-chloroquinolin-4-yl)amino]pentylamino]ethanol;DESETHYL HYDROXY CHLOROQUINE;2-[[(4RS)-4-[(7-Chloroquinolin-4-yl)amino]pentyl]amino]ethan-1-ol;Hydroxychloroquine EP Impurity C (Cletoquine);Hydroxychloroquine Sulphate Impurity 9;Hydroxychloroquine EP Impurity C (Phosphate);Ethanol, 2-[[4-[(7-chloro-4-quinolinyl)amino]pentyl]amino]-;Desethylhydroxychloroquine Dihydroc |
CAS号 | 4298-15-1 |
分子式 | C16H22ClN3O |
分子量 | 307.82 |
EINECS号 | 1308068-626-2 |
相关类别 | 医药原料药;对照品-杂质对照品;化学试剂;原料药;标准品;医药原料;杂质对照品;Metabolite;API |
Mol文件 | 4298-15-1.mol |
结构式 |
克尼托喹 性质
熔点 | 112-115°C |
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沸点 | 514.7±50.0 °C(Predicted) |
密度 | 1.212±0.06 g/cm3(Predicted) |
储存条件 | Hygroscopic, Refrigerator, under inert atmosphere |
溶解度 | 可溶于氯仿(轻微、加热)、DMSO(轻微)、甲醇(轻微) |
酸度系数(pKa) | 14.80±0.10(Predicted) |
形态 | 固体 |
颜色 | 灰白色至黄色 |
稳定性 | 吸湿性 |
Chikungunya virus (CHIKV)
Hydroxychloroquine (5 mg/kg intravenously) is administered to BALB/c mice for blood and tissue to determine the content of Cletoquine (Desethylhydroxychloroquine). The tissue to blood concentration ratio (Kp) is ≥1, indicating accumulation of Cletoquine in tissues. The Cletoquine Kp ratio for the various tissues are observed in the descending order of liver (114.3)>kidney (24.4)>spleen (19.3)>lungs (16.5)>heart (5.5).