罗汉果醇
中文名称 | 罗汉果醇 |
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中文同义词 | 罗汉果醇;罗汉果醇, >98%;ERK1/2和STAT3信号通路抑制剂(MOGROL);罗汉果甜苷元;葫芦素,罗汉果醇 |
英文名称 | (10α,24R)-9β-Methyl-19-norlanosta-5-ene-3β,11α,24,25-tetrol |
英文同义词 | (10α,24R)-3β,11α,24,25-Tetrahydroxy-9β-methyl-19-norlanosta-5-ene;(10α,24R)-9β-Methyl-19-norlanosta-5-ene-3β,11α,24,25-tetrol;(24R)-Cucurbit-5-ene-3β,11α,24,25-tetrol;Mogrol;Mogrol, >98%;(10α,24R)-9β-Methyl-19-norlanosta-5-ene-3β,11α,24,25-tetrol;ERK,inhibit,Extracellular signal regulated kinases,STAT,Mogrol,Inhibitor;Monascus alcohol |
CAS号 | 88930-15-8 |
分子式 | C30H52O4 |
分子量 | 476.73 |
EINECS号 | |
植物来源 | 罗汉果 |
相关类别 | 细胞生物学试剂;对照品;三萜;标准品,对照品 |
Mol文件 | 88930-15-8.mol |
结构式 |
罗汉果醇 性质
沸点 | 595.6±50.0 °C(Predicted) |
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密度 | 1.10±0.1 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | 溶于二甲基亚砜 |
形态 | 固体 |
酸度系数(pKa) | 14.67±0.29(Predicted) |
颜色 | 白色至米白色 |
CAS 数据库 | 88930-15-8 |
ERK1
|
ERK2
|
STAT3
|
Mogrol (0-250 µM) significantly and dose- and time-dependently inhibits K562 cell growth and increases the number of apoptotic cells. Mogrol (0, 10, 100, and 250 µM) induces G1 phase cell cycle arrest in K562 cells. Treatment with mogrol significantly decreases ERK phosphorylation as compared to control cells, whereas total ERK protein is not affected. Mogrol dose-dependently induces growth arrest in G0/G1 phase of the cell cycle. Mogrol significantly and dose-dependently enhances p21 protein expression in K562 cells. Mogrol significantly represses the increase in cellular TG levels induced by differentiation stimuli, and suppresses TG accumulation at micromolar levels, with a statistically significant suppression observed above 10 μM. Mogrol suppresses adipogenesis in 3T3-L1 cells at concentrations that does not affect cell viability. Mogrol suppresses adipogenesis through at least two different mechanisms, increasing AMPK phosphorylation and repressing the activation of CREB.
安全信息
海关编码 | 2934999090 |
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/11/08 | HY-N2312 | 罗汉果醇 Mogrol | 88930-15-8 | 1mg | 400元 |
2024/11/08 | HY-N2312 | 罗汉果醇 Mogrol | 88930-15-8 | 5mg | 850元 |