盐酸法倔唑

盐酸法倔唑

中文名称盐酸法倔唑
中文同义词法倔唑盐酸盐;4-(5,6,7,8-四氢咪唑并[1,5-A]吡啶-5-基)苯腈盐酸盐;盐酸法卓唑
英文名称FADROZOLE HYDROCHLORIDE
英文同义词FADROZOLE HYDROCHLORIDE;CGS-16949A;Fadrazole;D02451;Fadrozole hydrochloride (usan);4-(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile hydrochloride;4-(5,6,7,8-TETRAHYDROIMIDAZO[1,5-A]PYRIDIN-5-YL)BENZONITRILE(WXC09920);Fadrozole HCl
CAS号102676-31-3
分子式C14H13N3.ClH
分子量259.739
EINECS号
相关类别化学连接
Mol文件102676-31-3.mol
结构式盐酸法倔唑 结构式

盐酸法倔唑 性质

熔点231-233℃
储存条件room temp
溶解度二甲基亚砜:>20mg/mL
形态粉末
颜色淡米色至淡黄色
稳定性吸湿性

盐酸法倔唑 用途与合成方法

Fadrozole hydrochloride (CGS 16949A) 是一种有效,选择性和非甾体类的 aromatase 抑制剂,其 IC50 值为 6.4 nM。

IC50: 6.4 nM (aromatase)

Fadrozole hydrochloride is a potent, selective and nonsteroidal inhibitor of aromatase with an IC 50 of 6.4 nM. In hamster ovarian slices, Fadrozole hydrochloride inhibits the production of estrogen with an IC 50 of 0.03 μM. The production of progesterone is inhibited with an IC 50 of 120 μM. Synthesis of other cytochrome P-450 dependent steroids can be suppressed to various degrees with higher doses of Fadrozole hydrochloride.

Fadrozole hydrochloride is able to inhibit the aromatase-mediated uterine hypertrophy in immature female rats with an ED 50 of 0.03 mg/kg when given orally. In the same model, aminoglutethimide elicits the same effect with an ED 50 of 30 mg/kg when given orally. Fadrozole hydrochloride prevents the development of both benign and malignant spontaneus mammary neoplasns in female Sprague-Dawley rats. It also slows the spontaneous development of ptuitary pars distalis adenomas in female rats, and reduces the incidence of spontaneous hepatocellular tumours in male and female rats. Administration of Fadrozole hydrochloride in male and female mice accompanies with a 70% reduction in parasite burden. This protective effect is associated in male mice with a recovery of the specific cellular immune response. Interleukin-6 (IL-6) serum levels, and its production by splenocytes, is augmented by 80%, together with a 10-fold increase in its expression in testes of infected male mice. Fadrozole hydrochloride treatment returns these levels to baseline values.

安全信息

危险品标志Xn
危险类别码63-22
安全说明36/37
危险品运输编号UN 2811 6.1 / PGIII
WGK Germany2
RTECS号DI4952500

MSDS信息

更新日期产品编号产品名称CAS号包装价格
2024/11/08HY-14247盐酸法倔唑
Fadrozole hydrochloride
102676-31-35mg660元
2024/11/08HY-14247盐酸法倔唑
Fadrozole hydrochloride
102676-31-310mM * 1mLin DMSO726元
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