盐酸法倔唑
中文名称 | 盐酸法倔唑 |
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中文同义词 | 法倔唑盐酸盐;4-(5,6,7,8-四氢咪唑并[1,5-A]吡啶-5-基)苯腈盐酸盐;盐酸法卓唑 |
英文名称 | FADROZOLE HYDROCHLORIDE |
英文同义词 | FADROZOLE HYDROCHLORIDE;CGS-16949A;Fadrazole;D02451;Fadrozole hydrochloride (usan);4-(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile hydrochloride;4-(5,6,7,8-TETRAHYDROIMIDAZO[1,5-A]PYRIDIN-5-YL)BENZONITRILE(WXC09920);Fadrozole HCl |
CAS号 | 102676-31-3 |
分子式 | C14H13N3.ClH |
分子量 | 259.739 |
EINECS号 | |
相关类别 | 化学连接 |
Mol文件 | 102676-31-3.mol |
结构式 |
盐酸法倔唑 性质
熔点 | 231-233℃ |
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储存条件 | room temp |
溶解度 | 二甲基亚砜:>20mg/mL |
形态 | 粉末 |
颜色 | 淡米色至淡黄色 |
稳定性 | 吸湿性 |
IC50: 6.4 nM (aromatase)
Fadrozole hydrochloride is a potent, selective and nonsteroidal inhibitor of aromatase with an IC 50 of 6.4 nM. In hamster ovarian slices, Fadrozole hydrochloride inhibits the production of estrogen with an IC 50 of 0.03 μM. The production of progesterone is inhibited with an IC 50 of 120 μM. Synthesis of other cytochrome P-450 dependent steroids can be suppressed to various degrees with higher doses of Fadrozole hydrochloride.
Fadrozole hydrochloride is able to inhibit the aromatase-mediated uterine hypertrophy in immature female rats with an ED 50 of 0.03 mg/kg when given orally. In the same model, aminoglutethimide elicits the same effect with an ED 50 of 30 mg/kg when given orally. Fadrozole hydrochloride prevents the development of both benign and malignant spontaneus mammary neoplasns in female Sprague-Dawley rats. It also slows the spontaneous development of ptuitary pars distalis adenomas in female rats, and reduces the incidence of spontaneous hepatocellular tumours in male and female rats. Administration of Fadrozole hydrochloride in male and female mice accompanies with a 70% reduction in parasite burden. This protective effect is associated in male mice with a recovery of the specific cellular immune response. Interleukin-6 (IL-6) serum levels, and its production by splenocytes, is augmented by 80%, together with a 10-fold increase in its expression in testes of infected male mice. Fadrozole hydrochloride treatment returns these levels to baseline values.
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/11/08 | HY-14247 | 盐酸法倔唑 Fadrozole hydrochloride | 102676-31-3 | 5mg | 660元 |
2024/11/08 | HY-14247 | 盐酸法倔唑 Fadrozole hydrochloride | 102676-31-3 | 10mM * 1mLin DMSO | 726元 |