泽兰林素
中文名称 | 泽兰林素 |
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中文同义词 | 2-(3,4-二甲氧基苯基)-5,7-二羟基-6-甲氧基苯并吡喃-4-酮;异泽兰黄素;异泽兰黄素(标准品);艾叶浸膏 棕矢车菊素;异泽兰黄素(泽兰林素);异泽兰黄素(≥95%);EUPATILIN 异泽兰黄素(≥95%);泽兰林素;异泽兰黄素 |
英文名称 | eupatilin |
英文同义词 | 2-(3,4-Dimethoxyphenyl)-5,7-dihydroxy-6-methoxy-4H-1-benzopyran-4-one;5,7-Dihydroxy-3',4',6-trimethoxyflavone;2-(3,4-Dimethoxyphenyl)-5,7-dihydroxy-6-methoxychromen-4-one;4H-1-Benzopyran-4-one, 2-(3,4-diMethoxyphenyl)-5,7-dihydroxy-6-Methoxy-;eupatilin;Eupatilin 2-(3,4-Dimethoxyphenyl)-5,7-dihydroxy-6-methoxychromen-4-one;2-(3,4-Dimethoxyphenyl)-5,7-dihydroxy-6-methoxy-4H-chromen-4-one;2-(3,4-dimethoxyphenyl)-5,7-dihydroxy-6-methoxy-4H-chromen-4-one (EUPATILIN) |
CAS号 | 22368-21-4 |
分子式 | C18H16O7 |
分子量 | 344.32 |
EINECS号 | 618-347-7 |
植物来源 | 艾叶 |
相关类别 | 对照品;植提标准品;医药中间体;天然产物;中药对照品;标准品;植物提取物;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;标准品-中药标准品;黄酮;标准品 -中药标准品;标准品,对照品 |
Mol文件 | 22368-21-4.mol |
结构式 | ![]() |
泽兰林素 性质
熔点 | 236-238 °C |
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沸点 | 583.6±50.0 °C(Predicted) |
密度 | 1.387±0.06 g/cm3(Predicted) |
储存条件 | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
溶解度 | 可溶于乙腈(轻微)、DMSO(轻微)、甲醇(轻微、加热) |
形态 | 固体 |
酸度系数(pKa) | 6.47±0.40(Predicted) |
颜色 | 浅米色 |
稳定性 | 吸湿性 |
2.抑制肿瘤生长。
3.泽兰林素可用于治疗胃溃疡和镇痉。
4.调控血糖含量。
5.抗诱变因素的小生能。Eupatilin 是从蒿属植物中分到的亲脂性黄酮类化合物,是 PPARα 的激动剂,具有抗凋亡,抗氧化及抗炎等功效。
PPARα
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Eupatilin is a PPARα agonist. Eupatilin (10, 30, 100 μM) suppresses IL-4 expression and degranulation in RBL-2H3 cells. Eupatilin (50-100 μM) slightly reduces cell viability of HaCaT cells. Eupatilin (10, 30, 50, 100 μM) increases PPARα transactivation and expression in HaCaT cells. Eupatilin (10, 30, 50 μM) also suppresses TNFα-induced MMP-2/-9 expression in HaCaT cells. Furthermore, Eupatilin inhibits TNFα-induced p65 translocation, IκBα Phosphorylation, AP-1 and MAPK signaling via PPARα. Eupatilin (10-50 μM) shows no cytotoxic effects on ARPE19 cells. Eupatilin (10, 25, 50 μM) elevates cell viability from oxidative stress, and inhibits H 2 O 2 -induced ROS production in ARPE19 cells. Moreover, Eupatilin (50 μM) inbibits H 2 O 2 -induced cells apoptosis and promotes the activation of PI3K/Akt pathway in RPE cells.
Eupatilin (1.5% or 3.0%) restores PPARα mRNA expression, and improves atopic dermatitis (AD)-like symptoms in oxazolone-induced Balb/c mice. Eupatilin causes significant decrease in serum IgE, IL-4 levels, oxazolone-induced TNFα, IFNγ, IL-1β, TSLP, IL-33 and IL-25 mRNA expression in oxazolone-induced mice. Eupatilin also increases filaggrin and loricrin mRNA expression in oxazolone-induced mice.
药理药效:散热止痛, 温经止血,有治疗胃溃疡和镇痉的作用,能调控血糖
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-N0783 | 泽兰林素 Eupatilin | 22368-21-4 | 5mg | 766元 |
2024/08/19 | HY-N0783 | 泽兰林素 Eupatilin | 22368-21-4 | 10mM * 1mLin DMSO | 847元 |