11-氧-罗汉果皂甙V
| 中文名称 | 11-氧-罗汉果皂甙V |
|---|---|
| 中文同义词 | 11-O-罗汉果苷Ⅴ;11-氧-罗汉果皂甙V;11-O-罗汉果苷V;11-0-罗汉果苷V;11-氧-罗汉果苷V;11-氧罗汉果皂苷V;11-O-罗汉果苷5;11-氧-罗汉果苷V对照品 |
| 英文名称 | (24R)-3β-[6-O-(β-D-Glucopyranosyl)-β-D-glucopyranosyloxy]-24-[2-O,6-O-bis(β-D-glucopyranosyl)-β-D-glucopyranosyloxy]25-hydroxycucurbita-5-ene-11-one |
| 英文同义词 | 11-O-Mogroside V;(24R)-3β-[6-O-(β-D-Glucopyranosyl)-β-D-glucopyranosyloxy]-24-[2-O,6-O-bis(β-D-glucopyranosyl)-β-D-glucopyranosyloxy]-25-hydroxycucurbit-5-en-11-one;(24R)-3β-[6-O-(β-D-Glucopyranosyl)-β-D-glucopyranosyloxy]-24-[2-O,6-O-bis(β-D-glucopyranosyl)-β-D-glucopyranosyloxy]25-hydroxycucurbita-5-ene-11-one;11-Oxomogroside V;Mogroside V, 11-oxo-;(3beta,9beta,10alpha,24R)-24-[(O-beta-D-Glucopyranosyl-(1-2)-O-[beta-D-glucopyranosyl-(1-6)]-beta-D-glucopyranosyl)oxy]-3-[(6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]-25-hydroxy-9-methyl-19-norlanost-5-en-11-one;19-Norlanost-5-en-11-one, 24-[(O-β-D-glucopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→6)]-β-D-glucopyranosyl)oxy]-3-[(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-25-hydroxy-9-methyl-, (3β,9β,10α,24R)-;11-O momorin V |
| CAS号 | 126105-11-1 |
| 分子式 | C60H100O29 |
| 分子量 | 1285.42 |
| EINECS号 | 2017-001-1 |
| 植物来源 | 罗汉果 |
| 相关类别 | 标准品;对照品;中药对照品;植物提取物;分析试剂标准品;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;标准品-中药标准品;标准品 -中药标准品;标准品-对照品;标准品，对照品;提取物 |
| Mol文件 | 126105-11-1.mol |
| 结构式 |  |
11-氧-罗汉果皂甙V 性质
| 密度 | 1.51 |
|---|---|
| 储存条件 | 2-8°C |
| 溶解度 | 溶于甲醇和水 |
| 形态 | 粉末 |
| 酸度系数(pKa) | 12.82±0.70(Predicted) |
| 颜色 | 白色 |
罗汉果甜苷V(Mogroside V)是罗汉果中特有的一种葫芦烷型四环三萜皂苷，是罗汉果中主要的甜味成分，其甜度是蔗糖的300余倍，属低热量、非营养、非发酵型的天然高倍甜味剂。11-氧-罗汉果皂甙V同样是罗汉果中特有的一种葫芦烷型四环三萜皂苷，同样是一种天然甜味剂。在天然植物罗汉果中，11-氧-罗汉果皂甙V的含量比较低，仅仅是罗汉果甜苷V含量的10％～15％。目前获得高含量的11-氧-罗汉果皂甙V的方法，是通过物理方法从罗汉果提取物中富集、分离。
EC50: 4.79 μg/mL (O 2 - ), 16.52 μg/mL (H 2 O 2 ), 146.17 μg/mL (*OH)
11-oxo-mogroside V shows a higher scavenging effect on O 2 - (concentration at which 50% of chemiluminescence intensity is inhibited [EC 50 ]=4.79 μg/mL) and H 2 O 2 (EC 50 =16.52 μg/mL) than those of mogroside V. 11-oxo-mogroside V exhibits a remarkable inhibitory effect on *OH-induced DNA damage with EC 50 =3.09 μg/mL.11-oxo-mogroside V, a natural sweetener, isolated from the fruits of Momordica grosvenori , exhibits strong inhibitory effect on the primary screening test indicated by the induction of Epstein-Barr virus early antigen (EBV-EA) by a tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA). 11-oxo-mogroside V exhibits strong inhibitory effect on EBV-EA induction (91.2, 50.9 and 21.3% inhibition at 1000, 500 and 100 mol ratio/TPA concentration, respectively).
In the group treated with DMBA, TPA and 11-oxo-mogroside V, only 26.6 and 53.3% of mice bore papillomas even at 10 and 15 weeks of promotion, respectively, and only 1.0 3.3 and 4.7 papillomas are formed per mouse at 10, 15 and 20 weeks of promotion.
药理药效:抗癌的作用,抑制氧化作用。
安全信息
| 海关编码 | 29329990 |
|---|
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-N0501 | 11-氧-罗汉果皂甙V 11-oxo-mogroside V | 126105-11-1 | 1mg | 700元 |
| 2024/04/30 | HY-N0501 | 11-氧-罗汉果皂甙V 11-oxo-mogroside V | 126105-11-1 | 5mg | 1800元 |