DREADD AGONIST 21
| 中文名称 | DREADD AGONIST 21 |
|---|---|
| 中文同义词 | DREADD激动剂21;化合物DREADD AGONIST 21;11-(哌嗪-1-基)-5H-二苯并[B,E][1,4]二氮杂卓 |
| 英文名称 | 11-Piperazinyldibenzo[b,e][1,4]diazepine |
| 英文同义词 | 11-Piperazinyldibenzo[b,e][1,4]diazepine;DREADD Agonist 21;11-(1-Piperazinyl)-5H-dibenzo[b,e][1,4]diazepine;DREADD agonist 1;5H-Dibenzo[b,e][1,4]diazepine, 11-(1-piperazinyl)-;Muscarinic acetylcholine receptor,schizophrenia,mAChR,Inhibitor,muscarinic,disease,inhibit,DREADD agonist21,neurodegenerative,acetylcholine,DREADD agonist 21,DREADD,neuronal,hM3Dq,DREADD agonist-21,activation,receptors;11-(Piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine |
| CAS号 | 56296-18-5 |
| 分子式 | C17H18N4 |
| 分子量 | 278.35 |
| EINECS号 | |
| 相关类别 | 杂环,中间体;合成材料中间体 |
| Mol文件 | 56296-18-5.mol |
| 结构式 |  |
DREADD AGONIST 21 性质
| 沸点 | 470.1±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.28±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | DMSO:PBS (pH 7.2) (1:1):0.5(最大浓度 mg/mL);1.8(最大浓度 mM) 乙醇:29.61(最大浓度 mg/mL);106.39(最大浓度。 mM） |
| 形态 | 结晶固体 |
| 酸度系数(pKa) | 8.56±0.10(Predicted) |
| 颜色 | 粘黄色 |
| Target | Value |
|
hM3Dq
(Cell-free assay) | 1.7 nM(EC50) |
DREADD agonist 21 is a potent human muscarinic acetylcholine M3 receptors (hM3Dq) agonist (EC
50
=1.7 nM) and does not activate human M3 receptor (hM3). In addition to being inactive at hM3, DREADD agonist 21, a potent full agonist of hM3Dq (EC
50
=1.7 nM), is only 3.5-fold selective for hM3Dq over H1, 40-fold selective over 5HT2A, 100-fold selective over 5HT2C, and 165-fold selective over α1A. DREADD agonist 21 shows high binding affinities to 5HT2A and 5HT2C serotonin receptor, α1A adrenergic receptor, and H1 histamine receptor with K
i
values of 66, 170, 280, and 6 nM, respectively.
DREADD agonist 21 potently activates hM1Dq, hM3Dq, and hM4Di. DREADD agonist 21 binds to hM1, hM4, hM1Dq and hM4Di receptors with pK
i
s of 5.97, 5.44, 7.20, and 6.75, respectively. DREADD agonist 21 potently activates hM3Dq in Chinese hamster ovary (CHO) cells transfected cells in vitro with a pEC
50
of 8.48±0.05. DREADD agonist 21 is a highly selective and potent agonist for muscarinic DREADDs (pEC
50
for hM1Dq=6.54 and that for hM4Di=7.77 in pERK assays).
DREADD agonist 21 (0.3, 1.0, and 3.0 mg/kg; i.p.) activates neuronal hM3Dq in mice.
DREADD agonist 21 has excellent bioavailability, pharmacokinetic properties, and brain penetrability. DREADD agonist 21 (0.1, 1, and 10 mg/kg; i.p.) displays 95.1% plasma protein binding and 95% brain protein bounding in mice.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-100234 | DREADD AGONIST 21 DREADD agonist 21 | 56296-18-5 | 2mg | 600元 |
| 2024/04/30 | HY-100234 | DREADD AGONIST 21 DREADD agonist 21 | 56296-18-5 | 10mM * 1mLin DMSO | 920元 |