DL-肉碱盐酸盐
中文名称 | DL-肉碱盐酸盐 |
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中文同义词 | DL-肉碱盐酸盐, 98+%;DL-卡尼汀盐酸;DL-肉碱盐酸盐饲料级;DL-肉碱盐酸盐医药级;混旋肉堿盐酸盐;DL-肉碱盐酸盐(>98%,BR);混旋肉碱盐酸盐(99%);混旋肉碱盐酸盐 |
英文名称 | DL-Carnitine hydrochloride |
英文同义词 | (2,4-dihydroxy-4-keto-butyl)-trimethyl-ammonium chloride;(2,4-dihydroxy-4-oxo-butyl)-trimeth;(2,4-dihydroxy-4-oxo-butyl)-trimethyl-ammonium chloride;(2,4-dihydroxy-4-oxobutyl)-trimethylammonium chloride;3-carboxy-2-hydroxy-N,N,N-trimethylpropan-1-aminium chloride;3-hydroxy-4-trimethylazaniumylbutanoate hydrochloride;3-hydroxy-4-trimethylazaniumyl-butanoate hydrochloride;dl-bicarnesine hydrochloride |
CAS号 | 461-05-2 |
分子式 | C7H16ClNO3 |
分子量 | 197.66 |
EINECS号 | 207-309-1 |
相关类别 | 有机锡化合物;小分子抑制剂,天然产物;氨基酸衍生物;食品添加剂;化学生物学;其他生化试剂;医药中间体;Quaternary Ammonium Compounds;羰基化合物;维生素;医药原料;营养强化剂健胃素;饲料添加剂 营养强化剂健胃素;生化试剂;生化试剂-维生素类;标准品;中药对照品;原料;有机化工原料;精细化工原料;通用生化试剂-维生素;Fatty & Aliphatic Acids, Esters, Alcohols & Derivatives;Ammonium Chlorides (Quaternary);Amino Acids & Derivatives;Intermediates & Fine Chemicals;Isotope Labeled Compounds;Pharmaceuticals;Antiallergic agents;Inhibitors |
Mol文件 | 461-05-2.mol |
结构式 | ![]() |
DL-肉碱盐酸盐 性质
熔点 | 197-199 °C |
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比旋光度 | -0.2~+0.2°(20℃/D)(c=5,H2O) |
储存条件 | Store below +30°C. |
溶解度 | 可溶于水基(轻微)、甲醇(轻微、加热)、水(少量、超声处理) |
形态 | 粉末、晶体、针状物和/或块状物 |
颜色 | 白色到近乎白色 |
PH值 | 1.8-2.5 (100g/l, H2O) |
水溶解性 | SOLUBLE |
敏感性 | Hygroscopic |
Merck | 14,1849 |
BRN | 4163212 |
稳定性 | 吸湿性 |
InChIKey | JXXCENBLGFBQJM-UHFFFAOYSA-N |
CAS 数据库 | 461-05-2(CAS DataBase Reference) |
EPA化学物质信息 | 1-Propanaminium, 3-carboxy-2-hydroxy-N,N,N-trimethyl-, chloride (1:1) (461-05-2) |
DL-肉碱盐酸盐可用于食品添加剂和辅助治疗剂。
DL-肉碱盐酸盐是氨基酸赖氨酸和蛋氨酸生物合成的一种季铵化合物。
The main role of L-carnitine is to shuttle long-chain fatty acids across the inner mitochondrial membrane. After L-carnitine and acyl-CoA become acyl-carnitine by activation of carnitine palmitoyl transferase (CPT)-I, the transported acyl-carnitine is changed into acyl-CoA by CPT-II in the mitochondria matrix. Palmitoyl-CoA-induced mitochondrial respiration is increased by L-carnitine treatment, and then is accelerated by the presence of ADP. This acceleration is induced by treatment with L-carnitine in a concentration-dependent manner, and is saturated at 5 mM L-carnitine. Pretreatment with L-carnitine augments Nrf2 nuclear translocation, DNA binding activity and heme oxygenase-1 (HO-1) expression in H 2 O 2 -treated HL7702 cells. L-carnitine protects HL7702 cells against H 2 O 2 -induced cell damage through Akt-mediated activation of Nrf2 signaling pathway.
L-carnitine is found to down-regulate the ubiquitin proteasome pathway and increase IGF-1 concentrations in animal models. L-carnitine administration for 2 weeks of hindlimb suspension alleviates the decrease in weight and fiber size in the soleus muscle. In addition, L-carnitine suppresses atrogin-1 mRNA expression, which has been reported to play a pivotal role in muscle atrophy. Simultaneous treatment with L-carnitine attenuates the renal fibrosis (which correlated with a reduction of plasma TGF-β1 levels) and the pro-oxidative and proinflammatory status reported in L-NAME groups, with a concomitant increase in the expression of PPAR-γ.
安全信息
危险品标志 | Xi |
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危险类别码 | 36/37/38 |
安全说明 | 26-36-37/39 |
WGK Germany | 3 |
RTECS号 | BP2979140 |
TSCA | Yes |
海关编码 | 29239000 |
毒性 | LD50 subcutaneous in mouse: 6gm/kg |
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