| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:SC-51322
CAS:146032-79-3
Package:100Mg,10Mg
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| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:SC 51322;8-Chloro-2-[3-[(2-furanylMethyl)thio]-1-oxopropyl]-dibenz(Z)[b,f][1,4]oxazepine-10(11H)-carboxylicacidhydrazide
CAS:146032-79-3
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| Company Name: |
BOC Sciences
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| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:SC 51322
CAS:146032-79-3
Purity:98% by HPLC Remarks:SC 51322 is a potent EP1 prostanoid receptor antagonist (Ki = 13.8 nM) with analgesic properties in vivo. SC 51322 inhibits PGE2 signaling in a guinea pig ileum muscle strip assay with a pA2 value of
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| | SC-51322 Basic information |
| | SC-51322 Chemical Properties |
| Melting point | 112-114°C | | RTECS | HQ4002000 | | storage temp. | Store at +4°C | | solubility | DMSO: ≥10mg/mL | | form | powder | | color | white to off-white |
| Hazard Codes | T | | Risk Statements | 25 | | Safety Statements | 45 | | RIDADR | UN 2811 6.1 / PGIII | | WGK Germany | 3 | | HazardClass | 6.1 |
| | SC-51322 Usage And Synthesis |
| Description | The prostaglandin E2 (PGE2) receptor (EP1) is involved in triggering PGE2-mediated pain as well as neuronal survival and growth. SC-51322 is a selective EP1 antagonist that inhibits PGE2 signaling in a guinea pig ileum muscle strip assay with a pA2 value of 8.1 and demonstrates analgesic activity in a mouse writhing assay with an ED50 value of 0.9 mg/kg. It is pharmacologically similar to SC-51089, but does not release hydrazine, a known carcinogen to rats, as does SC-51089. SC-51322 potentiates the vasorelaxation of human pulmonary vein induced by PGE2 with an EC50 value of 7.75 μM. | | Chemical Properties | Off-White Solid | | Uses | A selective E-prostanoid receptor subtype 1 (EP1) receptor antagonist which shows antihypertensive effects. | | storage | Store at -20°C |
| | SC-51322 Preparation Products And Raw materials |
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