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| | 6-Chloropurine ribonucleoside Basic information |
| | 6-Chloropurine ribonucleoside Chemical Properties |
| Melting point | 158-162 °C (dec.)(lit.) | | Boiling point | 614.8±65.0 °C(Predicted) | | density | 1.7303 (rough estimate) | | refractive index | -45 ° (C=0.8, H2O) | | storage temp. | Sealed in dry,Store in freezer, under -20°C | | pka | 13.06±0.70(Predicted) | | form | Powder | | color | Yellow to Green | | CAS DataBase Reference | 2004-06-0(CAS DataBase Reference) |
| | 6-Chloropurine ribonucleoside Usage And Synthesis |
| Chemical Properties | white to light yellow crystal powde | | Uses | 6-CHLOROPURINE RIBOSIDE acts as a reactant in the synthesis of isozyme-specific enzyme inhibitors as well as in the preparation of dog coronary artery receptor agonists. | | Purification Methods | Purify the riboside by suspending the dry solid (~12 g) in hot MeOH (130 mL) and then adding enough hot H2O (~560mL) to cause solution, filter and set aside at 5o overnight. The colourless crystals of the riboside are filtered off, washed with Me2CO, Et2O and dried at 60o/0.1mm. More material can be obtained by evaporating the filtrate to dryness and recrystallisation of the residue from MeOH/H2O (2:1) (15mL/g). It has max 264nm ( 9140) in H2O. [Robins Biochemical Preparations 10 145 1963, Baker et al. J Org Chem 22 954 1957.] |
| | 6-Chloropurine ribonucleoside Preparation Products And Raw materials |
| Raw materials | [3,4-dibenzoyloxy-5-(6-chloropurin-9-yl)oxolan-2-yl]methyl benzoate-->2,3,5-TRI-O-ACETYL-6-CHLOROPURINE-9--D-RIBOFURANOSIDE-->TETRAACETYLRIBOFURANOSE-->1-O-ACETYL-2,3,5-TRI-O-BENZOYL-D-RIBOFURANOSE-->2',3',5'-Tri-O-acetyl-2-aMino-6-chloropurine Riboside-->2',3',5'-Tri-O-acetylinosine-->Uridine-->Inosine-->6-Chloropurine | | Preparation Products | 2-(6-ethylaminopurin-9-yl)-5-(hydroxymethyl)oxol-->N6-CYCLOHEXYLADENOSINE-->S-(4-NITROBENZYL)-6-THIOINOSINE-->Adenosine, N-(6-aminohexyl)--->6-Chloropurine -9-beta-D-(2'-deoxy-2'-fluoro)arabino-riboside-->TECADENOSON-->6-CHLOROPURINE RIBOSIDE-5'-O-MONOPHOSPHATE SODIUM SALT |
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