ML193
中文名称 | ML193 |
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中文同义词 | N-(4-(N-(3,4-二甲基异恶唑-5-基)氨磺酰基)苯基)-6,8-二甲基-2-(吡啶-2-基)喹啉-4-甲酰胺;ML 193,GPR55拮抗剂;N-(4-(N-(3,4-二甲基异噁唑-5-基)胺磺酰基)苯基)-6,8-二甲基-2-(吡啶-2-基)喹啉-4-甲酰胺 |
英文名称 | ML193 |
英文同义词 | ML193;N-[4-[[(3,4-Dimethyl-5-isoxazolyl)amino]sulfonyl]phenyl]-6,8-dimethyl-2-(2-pyridinyl)-4-quinolinecarboxamide;4-Quinolinecarboxamide, N-[4-[[(3,4-dimethyl-5-isoxazolyl)amino]sulfonyl]phenyl]-6,8-dimethyl-2-(2-pyridinyl)-;ML193 trifluoroacetate >=98% (HPLC);N-(4-(N-(3,4-Dimethylisoxazol-5-yl)sulfamoyl)phenyl)-6,8-dimethyl-2-(pyridin-2-yl)quinoline-4-carboxamide;CID 1261822;Inhibitor,deficits,motor,sensorimotor,CID-1261822,G protein-coupled receptor 55,disease,ML-193,Parkinson,ML193,CID1261822,ML 193,inhibit,GPR55 |
CAS号 | 713121-80-3 |
分子式 | C28H25N5O4S |
分子量 | 527.59 |
EINECS号 | |
相关类别 | |
Mol文件 | 713121-80-3.mol |
结构式 |
ML193 性质
储存条件 | Store at -20°C |
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溶解度 | 乙醇中≤0.1mg/ml;DMSO中≤2mg/ml;二甲基甲酰胺中≤3mg/ml |
形态 | 结晶固体 |
颜色 | 米白色至黄色 |
IC50: 221 nM (GPR55)
ML-193 (0.01-100 μM; pretreated for 15 min) inhibits β-arrestin trafficking induced by L-α-lysophophosphatidylinositol (LPI, 10 μM) and ML186 (1 μM) with IC
50
s of 0.22 μM and 0.12 μM, respectively.
ML-193 (0.01-10 μM; pretreated for 30 min) decreases the LPI-mediated ERK1/2 phosphorylation, with an IC
50
of 0.2 μM in U2OS cells.
ML-193 (5 μM; pretreated for 30 min) attenuates the GPR55 agonists induced increases in hNSCs proliferation rates.
ML-193 (5 μM; 10 d) attenuates the ML184-induced increases in hNSCs differentiation.
ML193 (1 and 5 µg/rat; intra-striatal at a rate of 1 μL/min) attenuates sensorimotor deficits and slip steps, increases motor coordination in PD rats.
Animal Model: | Male Wistar rats (200-250 g) were induced experimental Parkinson by 6-hydroxydopamine (6-OHDA, 10 µg/rat) |
Dosage: | 1 and 5 µg/rat |
Administration: | Injected into the right striatum at a rate of 1 μL/min |
Result: | Increased the time on the rotarod, decreased latency to remove the label and slip steps in 6-OHDA-lesioned rats. |
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-110125 | ML-193 | 1 mg | 400元 | |
2024/04/30 | HY-110125 | ML193 ML-193 | 713121-80-3 | 5mg | 850元 |