人参皂苷 RH3
中文名称 | 人参皂苷 RH3 |
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中文同义词 | 人参皂苷 S-RH3;人参皂苷RH3(标准品);人参皂苷 RH3;人参皂苷RH3对照品,;20(S)-人参皂苷RH3, 来源于人参根茎 |
英文名称 | ginsenoside Rh3 |
英文同义词 | [(20Z)-12β-Hydroxy-5α-dammara-20(22),24-dien-3β-yl]β-D-glucopyranoside;ginsenoside Rh3;b-D-Glucopyranoside, (3b,12b,20Z)-12-hydroxydammara-20(22),24-dien-3-yl;20(S)-Ginsenoside Rh3, 98%, from panax ginseng C. A. Mey.;β-D-Glucopyranoside, (3β,12β,20Z)-12-hydroxydammara-20(22),24-dien-3-yl;ginsenoside Rh3 USP/EP/BP;(2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-[[(8R,10R,12S,13R,14S,17S)-12-hydroxy-4,4,8,10,14-pentamethyl-17-[(2Z)-6-methylhepta-2,5-dien-2-yl]-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]oxane-3,4,5-triol |
CAS号 | 105558-26-7 |
分子式 | C36H60O7 |
分子量 | 604.86 |
EINECS号 | |
植物来源 | 人参 |
相关类别 | 中药对照品;标准品;生化试剂;对照品;植提标准品;植物提取物;分析试剂标准品;标准品-中药标准品;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Triterpenoids;标准品 -中药标准品;分析试剂-对照品;标准品-对照品 |
Mol文件 | 105558-26-7.mol |
结构式 |
人参皂苷 RH3 性质
沸点 | 695.0±55.0 °C(Predicted) |
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密度 | 1.17±0.1 g/cm3(Predicted) |
溶解度 | ≥ 28.75mg/mL,乙醇溶液,超声波和加热 |
酸度系数(pKa) | 12.91±0.70(Predicted) |
形态 | 固体 |
颜色 | 白色至米白色 |
人参皂苷Rh3是Rg5通过生物代谢转化而来的一种分子量更小的人参皂苷,它的功效比Rg5更强。
人参皂苷Rh3是人参皂苷Rg5 的代谢物,从人参中分离出来。人参皂苷 Rh3 可用作使用高效液相色谱结合蒸发光散射检测 (HPLC-ELSD) 测定高丽红参中人参皂苷 Rg5 的参考标准。Ginsenoside Rh3 是 Ginsenoside Rg5 的一种细菌代谢产物。在人视网膜细胞中 Ginsenoside Rh3 可诱导 Nrf2 激活。Nrf2
Ginsenoside Rh3 inhibits UV-induced oxidative damages in retinal cells via activating nuclear-factor-E2-related factor 2 (Nrf2) signaling. Ginsenoside Rh3 treatment in retinal cells induces Nrf2 activation. The potential activity of Ginsenoside Rh3 is tested on Nrf2 signaling in the retinal pigment epithelium cells (RPEs). The qRT-PCR assay results demonstrate that treatment with Ginsenoside Rh3 dose-dependently increases mRNA transcription and expression of key Nrf2-regulated genes, including HO1 , NQO1 and GCLC . Consequently, protein expressions of these Nrf2-dependent genes (HO1, NQO1 and GCLC) are also significantly increased in Ginsenoside Rh3 (3-10 μM)-treated RPEs. Notably, although Nrf2 mRNA level is unchanged after Ginsenoside Rh3 treatment, its protein level is significantly increased by Rh3. EZ-Cytox assay is used to assess the effect of ginsenoside-Rh3 on SP 1-keratinocytes viability. Ginsenoside Rh3 (0.01, 0.1, 1 and 10 μM) shows no cytotoxic effect at all concentrations.
The potential effect of Ginsenoside Rh3 is examined on mouse retina, using the light-induced retinal damage model. Ginsenoside Rh3 intravitreal injection (5 mg/kg body weight, 30 min pre-treatment) significantly attenuates light-induced decrease of both a- and b-wave amplitude. The electroretinography (ERG)'s a-wave decreases to 46.03±1.62% % of control level after light exposure, which is back to 71.84±7.51% with Ginsenoside Rh3 administration. The b-wave is 40.19±3.34% of control level by light exposure, and Rh3 intravitreal injection brings back to 80.01±2.37% of control level.
药理药效:具有抗炎作用,可显著抑制LPS诱导活化的小神经胶质细胞表达iNOs和前炎症细胞因子。
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-N0606 | Ginsenoside Rh3 | 1 mg | 1638元 | |
2024/08/19 | HY-N0606 | 人参皂苷 RH3 Ginsenoside Rh3 | 105558-26-7 | 5mg | 4300元 |