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Diethyl malate

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Diethyl malate Basic information
Product Name:Diethyl malate
Synonyms:2-hydroxy-butanedioicaciddiethylester;Butanedioicacid,hydroxy-,diethylester;hydroxy-butanedioicacidiethylester;FEMA 2374;ETHYL-DL-MALATE;DIETHYL MALATE;DIETHYL DL-MALATE;DL-MALIC ACID DIETHYL ESTER
CAS:7554-12-3
MF:C8H14O5
MW:190.19
EINECS:231-444-5
Product Categories:
Mol File:7554-12-3.mol
Diethyl malate Structure
Diethyl malate Chemical Properties
Boiling point 122-124 °C12 mm Hg(lit.)
density 1.128 g/mL at 25 °C(lit.)
refractive index 1.4330 to 1.4360
FEMA 2374 | DIETHYL MALATE
Fp 185 °F
storage temp. Sealed in dry,Room Temperature
solubility Chloroform (Sparingly), Ethyl Acetate (Slightly)
form clear liquid
pka12.35±0.20(Predicted)
color Colorless to Light yellow
Odorat 100.00 %. brown sugar sweet wine fruity herbal
Odor Typecaramellic
JECFA Number620
Dielectric constant10.2(18℃)
LogP0.23
EPA Substance Registry SystemButanedioic acid, hydroxy-, diethyl ester (7554-12-3)
Safety Information
WGK Germany 3
HS Code 2918.19.9000
MSDS Information
ProviderLanguage
SigmaAldrich English
Diethyl malate Usage And Synthesis
Chemical PropertiesDiethyl malate has a fruity odor with a pleasant herbaceous undertone. It is an ester of dicarboxylic acid
OccurrenceIt exhibits two optically active isomers in addition to the optically inactive form; the most common is the l-isomer; reported present in the cultures of certain fungi (Rhizopus). Reported found in raspberry, cognac, malt whiskey, cider, sherry, white, red, port, sparkling, rose, strawberry and bilberry wines
UsesDiethyl DL-Malate is used as a reagent in the synthesis of dicarboxylic nitroxyalkylamides and nitroxyalkylimides as anti-ischemic agents.
PreparationThe l-isomer can be prepared by esterification of the l-isomer of the acid with alcohol in the presence of HCl.
DefinitionChEBI: Diethyl malate is a malate ester obtained by the formal condensation of the two carboxy groups of malic acid with two molecules of ethanol respectively. It has a role as a metabolite.
ApplicationDiethyl malate is quite frequently used in flavour compositions, mainly for imitation Apples and Rum. The concentration in the finished consumer product may be about 20 to 25 ppm or up to 45 ppm in baked goods.
Synthesis Reference(s)Synthesis, p. 138, 1982 DOI: 10.1055/s-1982-29718
Diethyl malate Preparation Products And Raw materials
Raw materialsL-Malic acid-->YSAVZVORKRDODB-UHFFFAOYSA-N-->Diethyl fumarate-->Water-->Levulinic acid-->Ethanol-->2-Methyltetrahydrofuran-->DL-Malic acid-->Furfural
Tag:Diethyl malate(7554-12-3) Related Product Information
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