Биматопрост
Биматопрост атрибут
Температура плавления: |
66-68°C |
Температура кипения: |
629.8±55.0 °C(Predicted) |
плотность: |
1.145±0.06 g/cm3(Predicted) |
температура хранения: |
-20°C |
растворимость: |
Хлороформ (Мало растворим), дихлорметан (Мало растворим), метанол (Мало растворим) |
форма: |
Твердый |
пка: |
14.25±0.20(Predicted) |
цвет: |
От белого до не совсем белого |
BCS Class: |
3 |
Стабильность:: |
Светочувствительный |
ИнЧИКей: |
AQOKCDNYWBIDND-FTOWTWDKSA-N |
SMILES: |
C(NCC)(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1/C=C/[C@@H](O)CCC1=CC=CC=C1 |
Справочник по базе данных CAS: |
155206-00-1(CAS DataBase Reference) |
FDA UNII: |
QXS94885MZ |
Словарь онкологических терминов NCI: |
bimatoprost; Lumigan |
Код УВД: |
S01EE03 |
Биматопрост химические свойства, назначение, производство
Описание
Bimatoprost was first introduced in the US and Brazil as Lumigan?, an ophthalmic
solution (0.03%) for the reduction of elevated intraocular pressure (IOP) in patients with
open-angle glaucoma or ocular hypertension, a proven risk of glaucomatous visual field
loss. Bitamoprost is a new agent belonging to the PGF2α analog class of prostamides
launched in this indication after latanoprost, the most efficaceous topical medication
currently available. This synthetic fatty acid amide can be prepared by esterification of 17-
phenyl-18,19,20-trinorprostaglandin F2α followed by ethylamidation. Bimatoprost, as related
prostamides, is devoid of typical activities associated with PGF2,, analogs; it exhibits a
unique pharmacological profile in contracting the feline iris sphincter with an EC50 of 34 nM
without interacting with any known prostanoid receptors. Thus it mimics the action of
endogenous prostamides on specific receptors that lower IOP by increasing aqueous
humor outflow through both pressure-insensitive and pressure-sensitive pathways without
reducing humor formation. In a 3-month controlled clinical trial of efficacy and safety in patients with elevated IOP, bimatoprost demonstrated lower mean intraocular pressures at
every time point throughout the study, as well as a good tolerance and systemic safety
profile compared to latanoprost.
Химические свойства
Crystalline Solid
Использование
Bimatoprost is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension. It reduces intraocular pressure (IOP) by increasing the outflow of aqueous fluid from the eyes. It ha
Общее описание
Bimatoprost (Lumigan) is supplied as a sterile 0.03%ophthalmic solution in 2.5- and 5.0-mL sizes. The recommendeddosage of bimatoprost is limited to one drop intothe affected eye once daily in the evening. Increased usagemay decrease its beneficial effect. If used concurrently withother IOP-lowering drugs, a waiting period of 5 minutesshould separate administrations.
Биматопрост препаратная продукция и сырье
сырьё
препарат
Биматопрост поставщик
Global( 431)Suppliers
поставщик |
телефон |
страна |
номенклатура продукции |
благоприятные условия |
Xi'an Kono chem co., Ltd.,
|
029-86107037 13289246953
|
China |
2995 |
58 |
Henan Tianfu Chemical Co.,Ltd.
|
+86-0371-55170693 +86-19937530512
|
China |
21667 |
55 |
Shenzhen Monkono Technology Co.,Ltd
|
+86-17063441314
|
China |
677 |
58 |
Hangzhou Hyper Chemicals Limited
|
+86-0086-57187702781 +8613675893055
|
China |
277 |
58 |
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
|
+8615383190639
|
China |
1000 |
58 |
BINBO BIOLOGICAL CO.,LTD
|
+8618629063126
|
China |
346 |
58 |
airuikechemical co., ltd.
|
+undefined86-15315557071
|
China |
983 |
58 |
Wuhan Quanjinci New Material Co.,Ltd.
|
+8615271838296
|
China |
1534 |
58 |
Wuhan Haorong Biotechnology Co.,ltd
|
+86-18565342920; +8618565342920
|
China |
289 |
58 |
Guangzhou Tengyue Chemical Co., Ltd.
|
+86-86-18148706580 +8618826483838
|
China |
153 |
58 |
155206-00-1(Биматопрост)подобный поиск: