N-(2,6-ДИМЕТИЛФЕНИЛКАРБАМОИЛМЕТИЛ)ТРИЭТИЛАММОНИЯ ХЛОРИД химические свойства, назначение, производство
Использование
QX 314 chloride is a membrane-impermeant lidocaine derivative that selectively blocks sodium channels on nociceptive neurons when delivered intracellularly via the TRPV1 channel, but is reportedly ineffective with extracellular application. When supplied in combination with 1 μM capsaicin , a TRPV1 receptor agonist, 5 mM QX-314 blocks 98% of sodium current in voltage-clamped nociceptive DRG neurons. QX 314 chloride elicits a long-lasting decrease in the response to painful mechanical and thermal stimuli without imparting the motor deficits (e.g., numbness, paralysis) associated with many conventional local anesthetics. At concentrations ranging from 10-70 mM, peripheral application of QX 314 chloride dose-dependently produces robust local anesthesia with slow onset in the guinea pig intradermal wheal assay, the mouse tail-flick test, and the mouse sciatic nerve blockade model.
Биологическая активность
Membrane impermeable quaternary derivative of lidocaine, a blocker of voltage-activated Na + channels.
Биохимия/физиол Действия
Lidocaine N-ethyl chloride is an intracellular voltage-gated sodium channel blocker.
N-(2,6-ДИМЕТИЛФЕНИЛКАРБАМОИЛМЕТИЛ)ТРИЭТИЛАММОНИЯ ХЛОРИД препаратная продукция и сырье
сырьё
препарат