Propafenone Hydrochloride
Propafenone Hydrochloride атрибут
| Температура плавления: |
165-1670C |
| температура хранения: |
2-8°C |
| растворимость: |
Мало растворим в холодной воде, растворим в метаноле и горячей воде, практически не растворим в этаноле (96%). |
| форма: |
Solid |
| цвет: |
От белого до не совсем белого |
| λмакс: |
303nm(MeOH)(lit.) |
| Мерк: |
14,7794 |
| Справочник по базе данных CAS: |
34183-22-7(CAS DataBase Reference) |
| FDA UNII: |
33XCH0HOCD |
безопасность
- Заявления о рисках и безопасности
- код информации об опасности(GHS)
| Коды опасности |
T,Xn |
| Заявления о рисках |
46-22 |
| Заявления о безопасности |
53-36/37/39-45 |
| WGK Германия |
3 |
| RTECS |
UH2833000 |
| кода HS |
2922504500 |
| Токсичность |
LD50 in rats (mg/kg): 18.8 i.v.; 700 orally (Hapke, Prigge) |
| символ（GHS） |
|
| сигнальное слово |
Warning |
| Заявление об опасности |
| пароль |
Заявление об опасности |
Класс опасности |
категория |
сигнальное слово |
пиктограмма |
предупреждение |
| H302 |
Вредно при проглатывании. |
Острая токсичность, пероральная |
Категория 4 |
Предупреждение |
|
P264, P270, P301+P312, P330, P501 |
|
| Внимание |
| P301+P312+P330 |
ПРИ ПРОГЛАТЫВАНИИ: Обратиться за медицинской помощью
при плохом самочувствии. Прополоскать рот. |
|
Propafenone Hydrochloride химические свойства, назначение, производство
Описание
Propafenone hydrochloride is a class I anti-arrhythmic agent with basic local anaesthetic and membrane-stabilizing properties. Some P-adrenergic blocking action has also been described. Propafenone decreases the depolarization velocity and slows conduction in the His-Purkinje system with resultant increase in the PR interval and the QRS complex. Propafenone is used in the treatment of paroxysmal supraventricular tachycardias and ventricular arrhythmias.
Propafenone should not be used in uncontrolled cardiac failure, severe obstructive pulmonary disease or marked hypotension. Propafenone may worsen myasthenia gravis.
Химические свойства
White Solid
Использование
Propafenone hydrochloride is a class IC antiarrhythmic agent used for the management of severe ventricular and supraventricular arrhythmias. It has beta-blocking and weak calcium channel blocking properties, as well as some negative inotropic activity. Propafenone is in a class of medications called antiarrhythmics. It works by acting on the heart muscle to improve the heart's rhythm.
Использование
Sodium channel blocker. Antiarrhythmic (class IC)
Определение
ChEBI: Propafenone hydrochloride is a hydrochloride that is the monohydrochloride salt of propafenone. It is a class 1C antiarrhythmic drug with local anesthetic effects, and is used in the management of supraventricular and ventricular arrhythmias. It has a role as an anti-arrhythmia drug. It contains a propafenone(1+).
Фармакокине?тика
Propafenone hydrochloride (Rythmol(R)) is similar in action to flecainide. It reduces the fast inward sodium current in Purkinje fibres and to a lesser extent in myocardial fibres. Unlike other class l drugs, propafenone has mild B-blocking effects. This may contribute to its overall effects on the conduction system. lt is also believed to have calcium channel-blocking effects, which may contribute to its mild negative inotropic effects.
Propafenone Hydrochloride препаратная продукция и сырье
сырьё
препарат
Propafenone Hydrochloride поставщик
Global( 292)Suppliers
34183-22-7()подобный поиск: