Аденозин-5-трифосфорной кислоты динатриевая соль
Аденозин-5-трифосфорной кислоты динатриевая соль атрибут
| Температура плавления: |
188～190℃ |
| плотность: |
1.85 at 20℃ |
| давление пара: |
0.1Pa at 20-50℃ |
| температура хранения: |
-20°C |
| растворимость: |
H2O: 50 мг/мл |
| форма: |
Кристаллический |
| цвет: |
белый порошок |
| Водородный показатель: |
2.5 - 3.5 |
| Растворимость в воде: |
Растворим в воде |
| Мерк: |
155 |
| ИнЧИКей: |
TTWYZDPBDWHJOR-IDIVVRGQSA-L |
| LogP: |
-2.66 at 24℃ and pH7 |
| Surface tension: |
67.86mN/m at 1.019g/L and 20℃ |
| Справочник по базе данных CAS: |
987-65-5(CAS DataBase Reference) |
| FDA UNII: |
5L51B4DR1G |
| Система регистрации веществ EPA: |
Adenosine 5'-(tetrahydrogen triphosphate), disodium salt (987-65-5) |
Аденозин-5-трифосфорной кислоты динатриевая соль химические свойства, назначение, производство
Описание
ATP disodium salt (Adenosine 5'-triphosphate disodium salt) is an organic sodium salt. It consists of an ATP and a ({(2R,3S,4R,5R)-3,4-dihydroxy-5-(9h -purin-9-yl)oxolan-2-yl)methylphosphonatooxy)phosphonate. It has the role of providing a source of energy for cells and is a central component of energy storage and metabolism in the body. ATP disodium salt is an important endogenous signalling molecule in immunity and inflammation. It is an important component in the study of various physiological and biochemical processes. It is involved in a variety of cellular functions such as muscle contraction, nerve impulse transmission and membrane transport, making it a fundamental molecule for understanding biological mechanisms. It can also be used to photometrically determine Luc activity in cell extracts.
Химические свойства
White powder
Использование
A metabolite of Adenosine (A280400), a multifunctional nucleoside triphosphate used in cells as a coenzyme of intracellular energy transfer. It transports chemical energy within cells for metabolism. ATP Disodium Salt is used in the synthetic preparation of ribose-modified deoxyadenosine bisphosphate analogues as P2Y1 receptor ligands.
Биологическая активность
P2 purinoceptor agonist.
Оценка токсичности
ATP disodium salt was administered by gavage to rats for 90 consecutive days at doses of 0 (control), 500, 1000, and 2000 mg kg BW?1·d?1 (n = 10 per sex/group). Subchronic administration of ATP was well tolerated at all dose levels. Body weights and feed consumption body weight gains were similar between ATP-treated and control rats. Minor differences were seen in hematology and blood chemistry; however, these changes were not dose-related and, therefore, not of biological or toxicological significance. Only one difference was observed in absolute organ weights; females of the high dose had increased kidney and increased relative kidney and liver weights; however, these differences were not seen in males nor appeared to be dose-related[1].
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