6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone

64232-83-3

CAS №: 64232-83-3

английское имя:: 6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone

Синонимы:: L189;L 189;L189;(E)-6-amino-5-(benzylideneamino)-2-mercaptopyrimidin-4-ol;6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone;6-Amino-5-(benzylideneamino)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one;6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-thioxo-4(1H)-pyrimidinone;4(1H)-PyriMidinone, 6-aMino-2,3-dihydro-5-[(phenylMethylene)aMino]-2-thioxo-

CBNumber:: CB22518932

Формула:: C11H10N4OS

молекулярный вес:: 246.29

MOL File:: 64232-83-3.mol

атрибут

безопасность

использование

поставщик 72

продукт поиска:

6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone атрибут

Температура плавления:	250 °C (decomp)
плотность:	1.45±0.1 g/cm3(Predicted)
температура хранения:	Keep in dark place,Inert atmosphere,2-8°C
растворимость:	≥62,5 мг/мл в ДМСО; нерастворим в EtOH; нерастворим в H2O
форма:	Твердый
пка:	8.16±0.60(Predicted)
цвет:	Light yellow to yellow

Заявления о рисках и безопасности

6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone химические свойства, назначение, производство

Описание

L189 is a competitive inhibitor of DNA ligases I, III, and IV (IC₅₀s = 5, 9, and 5 μM, respectively). It blocks DNA binding (K_i = 5 μM for DNA ligase I), increasing the cytotoxicity of DNA-damaging agents, including ionizing radiation. L189 preferentially inhibits the interaction of the ligase with damaged DNA, inhibiting base excision repair and non-homologous end-joining.

Использование

L189 has been shown to inhibit DNA ligases I, III, and IV and may have potential use in the development of anticancer agents.

6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone препаратная продукция и сырье

сырьё

препарат

6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone поставщик

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Amadis Chemical Company Limited	571-89925085	China	131980	58
Aladdin Scientific	+1-+1(833)-552-7181	United States	57511	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	China	11681	58
TargetMol Chemicals Inc.	+1-781-999-5354	United States	19973	58
InvivoChem	+1-708-310-1919 +1-13798911105	United States	6393	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	China	30250	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32836	60
Suzhou Zhixin Biotechnology Co., Ltd.	0512-65118909 15162312715	China	2994	58
TargetMol Chemicals Inc.	4008200310	China	24647	58
Bide Pharmatech Ltd.	400-1647117 13681763483	China	62163	58