1,3-бензодиоксол химические свойства, назначение, производство
Описание
1,3-Benzodioxole, widely found in plant products, has shown potent antioxidant and antibacterial activities. It has recently been reported that 1,3-benzodioxole derivatives possess cytotoxic activity against several human tumor cell lines, including human colon carcinoma cells and multidrug-resistant nasopharyngeal carcinoma cells. No cytotoxic effects were noticed at a concentration of 10-4 M.
Химические свойства
clear colourless to light yellow liquid. Insoluble in acids.
Использование
1,3-Benzodioxole is useful in gemological stimulant detection. It is also used as a precursor for perfumes, photo initiators, agrochemicals and pharmaceuticals. 1,3-benzodimine is an intermediate for the synthesis of the drugs oxolinic acid, cinoxacin and miloxacin.
Методы производства
1,3-Benzodioxole is a colorless liquid. This compound is prepared by the reaction of catechol and dihalomethanes, for example, by use of concentrated aqueous alkaline solution in the presence of tetraalkylammonium or phosphonium salts, sometimes in the presence of alkyl iodides. 1,3-Benzodioxole is an important intermediate in organic synthesis, especially for the preparation of alkaloids.
прикладной
1,3-Benzodioxole belong to methylenedioxyphenyl (MDP) compounds that regulate cytochrome P 450-dependent drug oxidation, which is important in the process of eliminating drugs from the body. a hydrogen abstraction process can take place from the methylene-bridgea carbon of the benzodioxole compound and form a methylenedioxybenzene radical. It is therefore highly likely that 1,3-benzodioxole could serve as hydrogen donor for a CQ-based system initiating the photopolymerization of dental composite resin. In addition, 1,3-benzodioxole is an important organic intermediate (building block) to synthetize substituted methylenedioxybenzene products.
Определение
ChEBI: 1,3-benzodioxole is a benzodioxole consisting of a benzene ring substituted by a the methylenedioxy group.
Общее описание
Supersonic jet fluorescence spectra of 1,3-benzodioxole has been studied. The far-infrared spectrum of the vapour of 1,3-benzodioxole has been reported. The electronic absorption spectra and the laser-induced fluorescence spectra of supersonic-jet-cooled 1,3-benzodioxole molecules has been investigated.
1,3-бензодиоксол препаратная продукция и сырье
сырьё
препарат
Piperonyl chloride
3,4-Метилендиоксифенил-изотиоцианат
3,4-(Methylenedioxy)phenylacetonitrile
1,2-метилендиокси-4-нитробензола
Piperonyl aldehyde
4-нитроса
ПИПЕРОНИЛ ФОРМАЛЬДЕГИД
3-этокси-4-гидроксибензальдегид
HOMOPIPERONYLAMINE
(+/-)-1-(1,3-Benzodioxol-5-yl)-2-broMo-1-pentanone
5-ХЛОР-1,3-БЕНЗОДИОКСОЛ
N,N,N',N'-Тетраэтилметилендиамин
3,4-(МЕТИЛЕНДИОКСИ)БУТИРОФЕНОН
1,3-бензодиоксол-4-карбоновая кислота