Тебаин химические свойства, назначение, производство
Описание
The naturally occurring opiate alkaloid thebaine is
present in high concentrations in poppy straw; lower
concentrations of the co deine alkaloid are present.
Химические свойства
Tan Solid
Использование
Thebaine is present in opium at 0.3–1.5%.It is extracted from opium or from latex ofthe plant Papaver bracteatum, in which it ispresent at up to 26%. It is used to producecodeine.
Опасность
Toxic by ingestion, may induce addiction.
Угроза здоровью
Although thebaine has a morphine- orcodeine-like structure, its pharmacologyaction is somewhat different. It is a convulsantpoison like strychnine, rather thana narcotic. High doses can cause ataxia andconvulsion
LD50 value, intraperitoneal (mice): 42 mg/kg
Thebaine is a habit-forming compound. Itis a controlled substance (opiate) listed underU.S. Code of Federal Regulations (Title 21Part 1308.12, 1985).
Контактные аллергены
The naturally occurring opiate alkaloid thebaine is present in concentrated poppy straw, and in small concentrations in codeine alkaloid. It is used in the manufacture of other opiate pharmaceuticals, such as buprenorphine and morphine, and caused contact dermatitis in a laboratory worker at an opiates manufacturing pharmaceutical company, also sensitive to codeine.
Методы очистки
Crystallise Thebaine from Et2O or EtOH. Sublime it at 170-180o. The hydrochloride decomposes >182o (from MeOH/Et2O). [Beilstein 27 II 177, 27 III/IV 2271.] It is a NARCOTIC.
использованная литература
Pelletier, Thiboumery., Annalen, 16,38 (1835)
Kane., ibid, 19, 9 (1836)
Anderson., ibid, 86, 184 (1853)
Howerd., Ber., 17,527 (1884)
Pschorr, Zeidler., ibid, 27,2961 (1894)
Freund, Michaels, Gobel., ibid, 30, 1357 (1897)
Knorr., ibid, 36, 3074 (1903)
Freund, Holthof., ibid, 37, 2780 (1904)
Pschorr, Pfaff, Herrschmann., ibid, 38, 3163 (1905)
Reichard., Pharm. Zeit., 47,623 (1906)
Hildebrandt., Arch. expo Path. Pharm., 65,54 (1911)
Kruger, Eddy, Sumwalt., Suppl. No. 165, Public Health Reports, Washington
(1943)
Flieschhacker, Pasal, Vieboeck., Monatsh., 99, 300 (1968)
Eppenberger, Warren, Repoport., Helv. Chim. Acta, 51,381 (1968)
Тебаин препаратная продукция и сырье
сырьё
КОДЕИНОН
Morphinan, 6,7,8,14-tetradehydro-4,5-epoxy-3,6-dimethoxy-17-methyl-5-(trimethylsilyl)-, (5β)-
Morphinan, 7,8-didehydro-4,5-epoxy-3,6,6-trimethoxy-17-methyl-, (5α)-
(5alpha)-6,7-didehydro-4,5-epoxy-3,6-dimethoxy-17-methylmorphinan
Гидрокодон
6-O-METHYLCODEINE
Триметил ортоформиат
Кодеин
препарат
17-Нортебаин
СОЕДИНЕННЫЙ БИТАРТРАТ ГИДРОКОДОНА A CII (70 МГ) (МОРФИНАН-6-ОДИН, 4-ГИДРОКСИ-3-МЕТОКСИ-17-МЕТИЛ)
(4aS,7aR)-3,4,6,7,7a,8-Hexahydro-12-hydroxy-11-methoxy-7-methyldibenz[d,f]indol-2(5H)-one
(5alpha)-6,7,8,14-tetradehydro-4,5-epoxy-6-methoxy-17-methylmorphinan-3-ol
Naltrexone 3-Methyl Ether
OXYCODONE HYDROCHLORIDE