Триметил ортоформиат химические свойства, назначение, производство
Описание
Trimethyl orthoformate is an effective solvent for thallium(III) nitrate-mediated oxidations. It undergoes acid catalyzed reaction with 6-(N-D-ribitylanilino) uracils to form 8-demethyl-8-hydroxy-5-deazariboflavins.
Химические свойства
Colorless liquid. Slightly soluble in water, miscible with alcohol and oils.
Very diffusive, ethereal, pungent or nauseating odor, pleasant in dilution, slightly wineyfruity, Brandy-like.
Sweet taste in concentrations below 100 ppm.
Barely perceptible at 10 ppm.
Использование
Trimethyl Orthoformate is the most simple orthoester. Used in organic synthesis as a reagent for introducing a protecting group for aldehydes and in the creation of methoxymethylene groups and heterocyclic ring systems.
прикладной
Trimethyl orthoformate was used as dehydrating agent in the preparation of surface-modified colloidal silica nanoparticles.
MOM protection of Diols using Trimethyl Orthoformate
N-Formylation of Amino Acid Esters
Общее описание
Trimethyl orthoformate is an effective solvent for thallium(III) nitrate-mediated oxidations. It undergoes acid catalyzed reaction with 6-(N-D-ribitylanilino) uracils to form 8-demethyl-8-hydroxy-5-deazariboflavins.
Профиль безопасности
A skin and eye irritant.
A very dangerous fire hazard when exposed
to heat or flame; can react with oxidizing
materials. Hazardous to prepare. To fight
fire, use CO2, fog, haze. When heated to
decomposition it emits acrid smoke and
irritating fumes. See also ESTERS.
Меры предосторожности
Moisture sensitive. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with acids and strong oxidizing agents.
использованная литература
Protection for the Hydroxyl Group, Including 1,2- and 1,3-Diols
P. G. M. Wuts, in Greene's Protective Groups in Organic Synthesis, 5th ed., ed. by P. G. M. Wuts, John Wiley & Sons, Inc., Hoboken, New Jersey, 2014, Chap. 2, 17.
A Facile Procedure for the Synthesis of N-Formyl Amino Acid Esters
T. Chancellor, C. Morton, Synthesis 1994, 10, 1023.Триметил ортоформиат препаратная продукция и сырье
сырьё
препарат
6-bromoquinolin-4(3H)-one
6-Бром-4-хлорхинолина
5,6-DIHYDRO-4-METHOXY-2H-PYRAN
4-TRIFLUOROMETHYL-N-METHYLANILINE 97
Пипемидовая кислота
Метил метансульфона
3-МЕТОКСИ-Н-МЕТИЛАНИЛИН
N-метил-p-анизидин
ETHYL 5-AMINO-1-PYRIDIN-2-YL-1H-PYRAZOLE-4-CARBOXYLATE
N-Boc-5,6,7,8-tetrahydro-3-methoxy-[1,2,4]triazolo[4,3-A]pyrazine ,98%
Метил трифторацета
4,7-диметокси-1,10-фенантролин
Tetramethoxyethylene
Бромоформ
Тебаин
2-метилундеканаль диметилацеталь
(-)-диметил-D-тартрат
P-анисовый альдегид диметил ацетал
6,7-DIHYDRO-2-PHENYL-5H-PYRROLO[2,1-C]-1,2,4-TRIAZOLIUM CHLORIDE
BASIC RED 12