Диизопропиламин химические свойства, назначение, производство
Описание
Diisopropylamine is a secondary amine and is a colorless liquid at room temperature with a fishy, ammonia-like odor. It is used as a chemical intermediate, and catalyst for the synthesis of pesticides and pharmaceuticals. Diisopropylamine is associated with tobacco either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products. Synonyms for diisopropylamine include DIPA, and N-(1-methylethyl)-2- propanamine.
Химические свойства
Diisopropylamine is a flammable, strongly alkaline Colorless liquid. Diisopropylamine is soluble in water and alcohol. The odor threshold ranges from 0.017 to 4.2 ppm; the fishlike odor becomes irritating at 100 mg/m3.
Физические свойства
Colorless liquid with an ammonia-like odor. Experimentally determined detection and recognition
odor threshold concentrations were 50 μg/m3 (130 ppbv) and 190 μg/m3 (380 ppbv), respectively
(Hellman and Small, 1974).
прикладной
Diisopropylamine is used as a solvent and in the chemical synthesis of dyes, pharmaceuticals, and other organic syntheses. It used to synthesize diisopropylamine methyl urea (DMU), N,N-diisopropyl quinoline-2-carboxamide, 3-N-sulfonylamidine coumarins and N-chloroamine, an intermediate to generate amides.
Общее описание
Diisopropylamine appears as a clear colorless liquid with an ammonia-like odor. Flash point 30°F. Less dense than water. Vapors heavier than air. Toxic oxides of nitrogen produced during combustion. Used to make other chemicals.
Реакции воздуха и воды
Highly flammable. Soluble in water. Sensitive to heat and air.
Профиль реактивности
Diisopropylamine can react violently with oxidizing agents and strong acids. Readily eutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
Угроза здоровью
Permitted levels of diisopropylamine should not cause adverse health and welfare effects. Acute inhalation exposure to diisopropylamine can cause sore throat, cough, burning sensation and shortness of breath. Adverse effects occur mainly in the upper respiratory tract, although after chronic exposure. There is no definitive evidence that diisopropylamine causes cancer so a chronic cancer value was not developed. Diisopropylamine has not been classified as causing cancer by the International Agency for Research on Cancer, the United States Environmental Protection Agency, the American Conference of Industrial Hygienists, or the National Toxicology Program.
Химическая реактивность
Reactivity with Water No reaction; Reactivity with Common Materials: May attack some forms of plastics; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.
Промышленное использование
Diisopropylamine is used as a catalyst and as a stabilizer for mesityl oxide (HSDB
1989). It is also used as an intermediate in the synthesis of dyes, pharmaceuticals
and pesticides (e.g. Diallate, Fenamiphos and Triallate).
Профиль безопасности
Moderately toxic by
ingestion and subcutaneous routes. Mildly
toxic by inhalation. Mutation data reported.
A skin and severe eye irritant. Inhalation of
fumes can cause pulmonary edema. A very
dangerous fire hazard when exposed to heat
or flame; can react vigorously with oxidizing
materials. To fight fire, use alcohol foam,foam, CO2, dry chemical. When heated to
decomposition it emits toxic fumes of NOx
See also AMINES.
Экологическая судьба
Photolytic. Low et al. (1991) reported that the photooxidation of aqueous secondary amine
solutions by UV light in the presence of titanium dioxide resulted in the formation of ammonium
and nitrate ions.
Chemical/Physical. Reacts with acids forming water-soluble salts.
Метаболизм
Little, if any investigation of the metabolism of short-chain aliphatic amines has
been reported and the best that can be done is to suggest some possible metabolic
routes. For example the flavin monooxygenase system could produce the hydroxylamine
through N-hydroxylation catalyzed by the flavin monooxygenase system
(Ziegler 1988). N-hydroxylation can also be induced with the cytochrome P-450
system as can N-dealkylation reactions (Lindeke and Cho 1982). More definitive
analysis must await experimental studies.
Методы очистки
Distil the amine from NaOH, or reflux it three minutes over Na wire or NaH, and distil it into a dry receiver under N2. [Beilstein 4 H 154, 4 I 369, 4 II 630, 4 III 274, 4 IV 510.]
Диизопропиламин препаратная продукция и сырье
сырьё
препарат