Sarpogrelate hydrochloride
Sarpogrelate hydrochloride атрибут
| Температура плавления: |
145-148°C |
| температура хранения: |
Inert atmosphere,2-8°C |
| растворимость: |
деионизированная вода: ≥5 мг/мл |
| форма: |
Твердый |
| цвет: |
White to off-white |
| ИнЧИКей: |
POQBIDFFYCYHOB-UHFFFAOYSA-N |
| Справочник по базе данных CAS: |
135159-51-2(CAS DataBase Reference) |
| FDA UNII: |
FQN8N8QP1B |
Sarpogrelate hydrochloride химические свойства, назначение, производство
Описание
Sarpogrelate hydrochloride, a potent and selective serotonin 5-HT2 receptor
antagonist, was launched in Japan as an antithrombotic. It exhibits inhibition of ex vivo
platelet aggregation stimulated by serotonin in combination with collagen and suppression of
blood vessel constriction mediated by 5-HT2 in vitro. Its antithrombotic effects have been
demonstrated in several in vivo experimental models including reduction of the mortality rate in
acute pulmonary thromboembolic disease, arterial thrombosis, and peripheral obstructive
disease. Sarpogrelate has been shown to be especially useful as an antiplatelet agent for
patients with Type 2 diabetes mellitus, in whom 5-HT2mediated amplification of collageninduced
platelet aggregation is significantly increased.
Химические свойства
White Solid
Использование
Sarpogrelate hydrochloride is a potent and selective 5-HT2A receptor antagonist
ress-induced hemolysis.
Биологическая активность
Selective 5-HT 2A receptor antagonist (pK i values are 8.52, 7.43 and 6.57 for 5-HT 2A , 5-HT 2C and 5-HT 2B receptors respectively). Displays selectivity over 5-HT 1 , 5-HT 3 , 5-HT 4 H 1 , H 2 , M 3 , α 1 -adrenergic, α 2 -adrenergic and β -adrenergic receptors. Displays cardioprotective activity in vivo .
Sarpogrelate hydrochloride препаратная продукция и сырье
сырьё
препарат
Sarpogrelate hydrochloride поставщик
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