G-STROPHANTHIN химические свойства, назначение, производство
Описание
One of several
cardiac glycosides that have been used clinically as cardiotonic
agents and diuretics. Ouabain is obtained from the seeds of
Strophanthus gratus, Acokanthera ouabaio, and related species.
It was formerly prescribed under the name strophanthuis as the
purified seed extract.
Химические свойства
Ouabain is a white crystalline solid.
Общее описание
Odorless, white crystals or crystalline powder as an octahydrate. Used to produce rapid digitalization in acute congestive heart failure. Also recommended in treatment of atrial or nodal paroxysmal tachycardia and atrial flutter.
Профиль реактивности
When heated to decomposition, G-STROPHANTHIN emits acrid smoke and fumes. Hydrolysis yields one mole ouabagenin and one mole rhamnose. Stable in air, but affected by light (G-STROPHANTHIN octahydrate) [EPA, 1998].
Угроза здоровью
G-STROPHANTHIN is classified as extremely toxic. Probable oral lethal dose in humans is less than 5 mg/kg or a taste (less than 7 drops) for 70 kg (150-lb.) person. Exposure may result in respiratory and cardiac failure, and/or hyperalkemia. Patients with frequent premature ventricular heart beats or who have received any preparation of digitalis during preceding three weeks are prone to toxicity.
Пожароопасность
When heated to decomposition, G-STROPHANTHIN emits acrid smoke and fumes. Hydrolysis yields one mole ouabagenin and one mole rhamnose. Stable in air, but affected by light (G-STROPHANTHIN octahydrate)
Биологическая активность
Selective Na + , K + -ATPase inhibitor.
Профиль безопасности
Poison by ingestion, intramuscular, intraperitoneal, intravenous, subcutaneous, and parented routes. Moderately toxic by intraduodenal route. A cardac stimulant. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes
Возможный контакт
Ouabain, similar to digitoxin, is used
to produce rapid digitalization in acute congestive heart
failure. Also recommended in treatment of atrial or nodal
paroxysmal tachycardia and atrial flutter; enzyme inhibitor.
Перевозки
UN1544 Alkaloids, solid, n.o.s., Hazard Class:
6.1; Labels: 6.1-Poisonous materials.
Методы очистки
It crystallises from water as the octahydrate. Dry it at 130o. It decomposes at 190o when dry. Store it in the dark as it is light sensitive, but it is stable in air. Its solubility (g/100mL) in H2O is 1.3 (~25o), 20 (~100o), and in EtOH it is 1.0 (~25o) and 12.5 (~78o). It is highly TOXIC as it is an inhibitor of cation transport and of Na+ and K+ ATPase. [Beilstein 18/5 V 625.]
Несовместимости
Incompatible with oxidizers (chlorates,
nitrates, peroxides, permanganates, perchlorates, chlorine,
bromine, fluorine, etc.).
G-STROPHANTHIN препаратная продукция и сырье
сырьё
препарат