Хлоротиазид химические свойства, назначение, производство
Описание
Chlorothiazide is a first-in-class thiazide diuretic initially discovered from its ability to inhibit carbonic anhydrase in vitro. As an antihypertensive agent, this thiazide increases renal excretion of sodium, potassium, chloride, and bicarbonate ions by inhibiting tubular reabsorptive mechanisms.
Химические свойства
Off-White Solid
Использование
Chlorthiazide is a diuretic that causes the body to excrete excess fluid. This drug exhibits strong diuretic action during both acidosis and alkalosis. It is used for arterial hypertension, in edematous syndromes of various genesis, congestive effects in cardiovascular insufficiency, nephrosis and nephritis, and toxicosis. It is especially recommended for hypertonic illnesses. It lowers intraocular pressure in a number of cases.
Определение
ChEBI: Chlorothiazide is 4H-1,2,4-benzothiadiazine 1,1-dioxide in which the hydrogen at position is substituted by chlorine and that at position 7 is substituted by a sulfonamide group. A diuretic, it is used for treatment of oedema and hypertension. It has a role as a diuretic and an antihypertensive agent.
Общее описание
Crystals; white powder.
Реакции воздуха и воды
Insoluble in water.
Профиль реактивности
Alkaline aqueous solutions will decompose on standing or heating .
Пожароопасность
Flash point data for Chlorothiazide are not available; however, Chlorothiazide is probably combustible.
Механизм действия
The mechanism of action of Chlorothiazide is an interference with the renal tubular mechanism of electrolyte reabsorption. The diuretic action of chlorothiazide, like other drugs of this series, is caused by reduced absorption of sodium and chloride ions by the kidneys during their simultaneous, intense excretion from the organism.
Профиль безопасности
Moderately_toxic by
intraperitoneal and intravenous routes.
Mddly toxic by ingestion. Experimental
reproductive effects. Has been implicated in
aplastic anemia. When heated to
decomposition it emits very toxic fumes of
SOx NOx and Cl-.
Хлоротиазид препаратная продукция и сырье
сырьё
препарат