Бутанол химические свойства, назначение, производство
Описание
n-Butyl alcohol is a colourless flammable liquid with strong alcoholic odour. n-Butyl alcohol
is a highly refractive liquid and burns with a strongly luminous flame. It is incompatible
with strong acids, strong oxidising agents, aluminium, acid chlorides, acid anhydrides,
copper, and copper alloys. n-Butyl alcohol has an extensive use in a large number of industries.
For instance, it is used as solvent in industries associated with the manufacturing of
paints, varnishes, synthetic resins, gums, pharmaceuticals, vegetable oils, dyes, and alkaloids.
n-Butyl alcohol finds its use in the manufacture of artificial leather, rubber, plastic
cements, shellac, raincoats, perfumes, and photographic films.
Химические свойства
1-Butanol is a colorless, volatile liquid with a rancid sweet odor. The air odor threshold of 1-butanol was reported to be 0.83 ppm ; others have identified the minimum concentration with identifiable odor as 11 and 15 ppm.
Физические свойства
Clear, colorless liquid with a rancid sweet odor similar to fusel oil. Experimentally determined
detection and recognition odor threshold concentrations were 900 μg/m3 (300 ppbv) and 3.0 mg/m3
(1.0 ppmv), respectively (Hellman and Small, 1974). Odor threshold concentration in water is 500
ppb (Buttery et al., 1988). The least detectable odor threshold in concentration water at 60 °C was
0.2 mg/L (Alexander et al., 1982). Cometto-Mu?iz et al. (2000) reported nasal pungency threshold
concentrations ranging from approximately 900 to 4,000 ppm.
Вхождение
1-Butanol is a natural product found in Vitis rotundifolia, Cichorium endivia, peppermint oil from Brazil, Achillea ageratum, tea, apple aroma, American cranberry, black currants, guava fruit, papaya, cooked asparagus, tomato, Swiss cheese, Parmesan cheese, heated butter, cognac, Armagnac, rum and cider.
Использование
1-Butanol is used in the production of butylacetate, butyl glycol ether, and plasticizerssuch as dibutyl phthalate; as a solvent in thecoating industry; as a solvent for extractionsof oils, drugs, and cosmetic nail products;and as an ingredient for perfumes and flavor.
1-Butanol occurs in fusel oil and as aby-product of the fermentation of alcoholicbeverages such as beer or wine. It is presentin beef fat, chicken broth, and nonfilteredcigarette smoke (Sherman 1979).
Методы производства
The principal commercial source of 1-butanol is n-butyraldehyde
obtained from the oxo reaction of propylene,
followed by hydrogenation in the presence of a catalyst
. 1-Butanol has also been produced from
ethanol via successive dehydrogenation to acetaldehyde,
followed by an aldol process. The earliest commercial
route to 1-butanol, which is still used extensively
in many Third World countries, employs fermentation
of molasses or corn products with Clostridium acetobutylicum
.
Определение
ChEBI: 1-Butanol is a primary alcohol that is butane in which a hydrogen of one of the methyl groups is substituted by a hydroxy group. It it produced in small amounts in humans by the gut microbes. It has a role as a protic solvent, a human metabolite and a mouse metabolite. It is a primary alcohol, a short-chain primary fatty alcohol and an alkyl alcohol.
Общее описание
Colorless liquid. Used in organic chemical synthesis, plasticizers, detergents, etc.
Реакции воздуха и воды
Highly flammable. Soluble in water.
Профиль реактивности
1-Butanol attacks plastics. [Handling Chemicals Safely 1980. p. 236]. Mixtures with concentrated sulfuric acid and strong hydrogen peroxide can cause explosions. May form explosive butyl hypochlorite by reacting with hypochlorous acid. May form butyl explosive butyl hypochlorite with chlorine.
Опасность
Toxic on prolonged inhalation, irritant to
eyes. Toxic when absorbed by skin. Flammable,
moderate fire risk. Eye and upper respiratory tract
irritant.
Угроза здоровью
The toxicity of 1-butanol is lower than thatof its carbon analog. Target organs are theskin, eyes, and respiratory system. Inhalationcauses irritation of the eyes, nose, and throat.It was found to cause severe injury to rabbits’eyes and to penetrate the cornea uponinstillation into the eyes. Chronic exposureof humans to high concentrations may causephotophobia, blurred vision, and lacrimation.
A concentration of 8000 ppm was maternallytoxic to rats, causing reduced weightgain and feed intake. Teratogenicity wasobserved at this concentration with a slightincrease in skeletal malformations (Nelsonet al. 1989).
In a single acute oral dose, the LD50 value(rats) is 790 mg/kg; in a dermal dose theLD50 value (rabbits) is 4200 mg/kg.
n-Butanol is oxidized in vivo enzymaticallyas well as nonenzymatically and iseliminated rapidly from the body in the urineand in expired air. It inhibits the metabolismof ethanol caused by the enzyme alcoholdehydrogenase.
Based on the available data, the useof n-butanol as an ingredient is consideredsafe under the present practices andconcentrations in cosmetic nail products(Cosmetic, Toiletry and Fragrance Association1987a).
Пожароопасность
HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
Профиль безопасности
A poison by intravenous route. Moderately toxic by skin Review: Group 3 IMEMDT 7,56,87; Animal Inadequate Evidence IMEMDT 39,67,86* contact, ingestion, subcutaneous, and intraperitoneal routes. Human systemic Reported in EPA TSCA Inventory. Community fight-To-Ihow List. OSHA PEL: TWA 10 pprn Classifiable as a Carcinogen DFG MAK: 2 ppm (11 mg/m3) DOT CLASSIFICATION: 3; Label: Flammable Liquid ingestion, inhalation, skin contact, and intraperitoneal routes. Experimental reproductive effects. A skin and eye irritant. Questionable carcinogen. A flammable fight fire, use foam, CO2, dry chemical. Incompatible with oxidzing materials. When heated to decomposition it emits acrid and irritating fumes. See also ESTERS. effects by inhalation: conjunctiva irritation, unspecified respiratory system effects, and nasal effects. Experimental reproductive Though animal experiments have shown the butyl alcohols to possess toxic properties, they have produced few cases of poisoning in industry, probably because of their low reported to have resulted in irritation of the eyes, with corneal inflammation, slight headache and H2ziness, slight irritation of the nose and throat, and dermatitis about fingers. Keratitis has also been reported. Mutation data reported.
Возможный контакт
Butyl alcohols are used as solvents for
paints, lacquers, varnishes, natural and synthetic resins,
gums, vegetable oils, dyes, camphor, and alkaloids. They
are also used as an intermediate in the manufacture of pharmaceuticals and chemicals; in the manufacture of artificial
leather, safety glass; rubber and plastic cements, shellac,
raincoats, photographic films, perfumes; and in plastic
fabrication.
Описание
Бутиловый спирт (бутанол) — бесцветная, чуть маслянистая жидкость с характерным запахом сивушного масла. Ограниченно растворим в воде.
Химические свойства
Бесцветная, не агрессивная жидкость.Стабильный. Очень огнеопасен. Несовместим с сильными окислителями, медью, медными сплавами, щелочными металлами, алюминием.
Применение
Бутанол-Применяется как сырье в различных органических синтезах, например, в производстве пластификаторов (компонентов полимерных материалов, увеличивающих их эластичность).
Производство
восстановительное карбонилирование пропилена (образуется смесь бутилового спирта и изобутилового спирта), альдольная конденсация ацетальдегида с последующей дегидратацией и гидрированием.
токсичности
Токсичность бутанола относительно невелика (LD50 составляет 2290–4360 мг/кг), но наивысшая среди младших спиртов.
хранилище
Store n-butyl alcohol in a cool, dry, well-ventilated location, away from smoking areas.
Fire hazard may be acute. Outside or detached storage is preferred. Separate from
incompatibles. Containers should be bonded and grounded for transfer to avoid static
sparks
Перевозки
UN1120 Butanols, Hazard Class: 3; Labels: 3—
Flammable liquid. UN1212 Isobutanol or Isobutyl alcohol,
Hazard Class: 3; Labels: 3—Flammable liquid
Методы очистки
Dry it with MgSO4, CaO, K2CO3, or solid NaOH, followed by refluxing with, and distillation from, small amounts of calcium, magnesium activated with iodine, or aluminium amalgam. It can also be dried with molecular sieves, or by refluxing with n-butyl phthalate or succinate. (For method, see Ethanol.) n-Butanol can also be dried by efficient fractional distillation, water passing over in the first fraction as a binary azeotrope (contains about 37% water). An ultraviolet-transparent distillate has been obtained by drying with magnesium and distilling from sulfanilic acid. To remove bases, aldehydes and ketones, the alcohol is washed with dilute H2SO4, then NaHSO4 solution; esters are removed by boiling for 1.5hours with 10% NaOH. It has also been purified by adding 2g NaBH4 to 1.5L butanol, gently bubbling with argon and refluxing for 1 day at 50o. Then adding 2g of freshly cut sodium (washed with butanol) and refluxed for 1day. Distil and collect the middle fraction [Jou & Freeman J Phys Chem 81 909 1977]. [Beilstein 1 IV 1506.]
Несовместимости
Butyl alcohols may form explosive mixture with air. In all cases they are Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates,
perchlorates, chlorine, bromine, fluorine, etc.); contact may
cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Attacks
some plastics, rubber and coatings. n-Butanol is incompatible with strong acids; halogens, caustics, alkali metals; aliphatic amines; isocyanates. sec-Butanol forms an explosive
peroxide in air. Ignites with chromium trioxide.
Incompatible with strong oxidizers; strong acids; aliphatic
amines; isocyanates, organic peroxides. tert-Butanol is
incompatible with strong acids (including mineral acid),
including mineral acids; strong oxidizers or caustics, aliphatic amines; isocyanates, alkali metals (i.e., lithium,
sodium, potassium, rubidium, cesium, francium). isoButanol is incompatible with strong acids; strong oxidizers;
caustics, aliphatic amines; isocyanates, alkali metals and
alkali earth. May react with aluminum at high temperatur
Утилизация отходов
Incineration, or bury absorbed
waste in an approved land fill.
Бутанол препаратная продукция и сырье
сырьё
препарат