(+)-1-дезоксинойиримицин
(+)-1-дезоксинойиримицин атрибут
| Температура плавления: |
195-196°C |
| Температура кипения: |
361.1±42.0 °C(Predicted) |
| плотность: |
1.456±0.06 g/cm3(Predicted) |
| давление пара: |
0Pa at 25℃ |
| RTECS: |
TN4350300 |
| температура хранения: |
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| растворимость: |
Растворим в воде до 25 мг/мл). |
| пка: |
13.77±0.70(Predicted) |
| форма: |
пудра |
| цвет: |
белый |
| Растворимость в воде: |
Растворим в воде, диметилсульфоксиде и метаноле. |
| БРН: |
3588039 |
| Стабильность:: |
Срок годности 2 года с даты покупки в состоянии поставки. Растворы в дистиллированной воде можно хранить при температуре -20° до 3 месяцев. |
| LogP: |
-1.8 |
| Справочник по базе данных CAS: |
19130-96-2(CAS DataBase Reference) |
| Рейтинг продуктов питания EWG: |
1 |
| FDA UNII: |
FZ56898FLE |
(+)-1-дезоксинойиримицин химические свойства, назначение, производство
Химические свойства
White Crystalline Solid
Вхождение
1-Deoxynojirimycin (DNJ), a product of fermentation, exists in mulberry leaves and Commelina communis (dayflower) as well as is isolated from several bacterial strains such as Bacillus and Streptomyces species. Mulberry, a common deciduous plant, belongs to the genus Morus (Moraceae family). Numerous researchers have reported the DJN contents in different parts and various varieties of mulberry. Various mulberry varieties contain DNJ contents ranging between 0.68 and 2.78 mg/gm, while this fraction varies between 1.57 and 3.48 mg/gm in different Chinese mulberry leaves. Moreover, mulberry shoots contain the highest contents of DNJ, followed by young mulberry leaves. Mature leaves of mulberry contain the least content of DNJ. All the mulberry leave groups showed a 1–2-fold increase in DNJ contents compared to unfermented mulberry leaf powder extract (UFMLE). Additionally, fermented mulberry leaf powder extract exhibited higher α-glucosidase activity than UFMLE. DNJ-rich food products can be prepared by fermenting mulberry leaves using the above-mentioned fermenting agents[6].
Использование
An alpha-glucosidase inhibitor. Interferes with normal processing of N-linked glycoproteins.(+)-1-Deoxynojirimycin acts as an inhibitor of alfa-glucosidase I and II and maltase-glucoamylase. It also inhibits mammalian glucosidase, intestinal and lysosmal, beta-glucosidase from sweet almonds, pancreatic alfa-amylase and amyloglucosidase. Further, it serves as a enzyme enhancer for the treatment of Fabry and Pompe disease.
Определение
ChEBI: An optically active form of 2-(hydroxymethyl)piperidine-3,4,5-triol having 2R,3R,4R,5S-configuration.
Биологическая активность
Inhibitor of glucosidase I (K i = 2.1 mM) and II (K i = 7 mM).
(+)-1-дезоксинойиримицин препаратная продукция и сырье
сырьё
препарат
(+)-1-дезоксинойиримицин поставщик
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